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Antimicrobial susceptibility and macrolide resistance inducibility of Streptococcus pneumoniae carrying erm(A), erm(B), or mef(A). | LitMetric
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Antimicrobial susceptibility and macrolide resistance inducibility of Streptococcus pneumoniae carrying erm(A), erm(B), or mef(A).

George A Syrogiannopoulos Ioanna N Grivea Lois M Ednie Bülent Bozdogan George D Katopodis Nicholas G Beratis Todd A Davies Peter C Appelbaum

Antimicrob Agents Chemother

Department of Pediatrics, General University Hospital, University of Patras, School of Medicine, Patras, Greece.

Published: August 2003

Erythromycin-resistant Streptococcus pneumoniae isolates from young carriers were tested for their antimicrobial susceptibility; additionally, inducibility of macrolide and clindamycin resistance was investigated in pneumococci carrying erm(A), erm(B), or mef(A). Of 125 strains tested, 101 (81%) were multidrug resistant. Different levels of induction were observed with erythromycin, miocamycin, and clindamycin in erm(B) strains; however, in erm(A) strains only erythromycin was an inducer. Induction did not affect macrolide MICs in mef(A) strains.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166089PMC
http://dx.doi.org/10.1128/AAC.47.8.2699-2702.2003DOI Listing

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