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Effects of CXCR1/2 Blockade with Ladarixin on Streptozotocin-Induced Type 1 Diabetes Mellitus and Peripheral Neuropathy and Retinopathy in Rat.
Diabetes Metab J
March 2025
R&D, Dompé Farmaceutici SpA, L'Aquila, Italy.
Background: The CXC motif chemokine ligand 8 (CXCL8)-CXC motif chemokine receptor 1/2 (CXCR1/2) axis has been implicated in type 1 diabetes mellitus (T1DM). Its actions on non-immune cells may also contribute to T1DM-associated complications, including painful diabetic peripheral neuropathy (DPN) and diabetic retinopathy (DR).
Methods: We assessed the efficacy of early (4-8 weeks) or late (8-12 weeks) daily ladarixin (LDX) for the treatment of streptozotocin (STZ)-induced T1DM and the related complications of DPN or DR in male rats.
M6A Modified miR-31-5p Suppresses M1 Macrophage Polarization and Autoimmune Dry Eye by Targeting P2RX7.
Adv Sci (Weinh)
March 2025
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300384, China.
The dysregulation of the M1/M2 macrophage balance plays a pivotal role in autoimmune diseases. However, the interplay between microRNAs (miRNAs) and N6-methyladenosine (m6A) modulation in regulating this balance remains poorly understood. Here, a significant reduction in miR-31-5p levels is observed in the lacrimal glands of rabbit autoimmune dacryoadenitis and the peripheral blood mononuclear cells (PBMCs) of Sjögren's syndrome (SS) dry eye patients.
View Article and Find Full Text PDFMULTIMODAL IMAGING IN DEFEROXAMINE-RELATED OCULAR TOXICITY: RAPID DEVELOPMENT DUE TO SUPRATHERPEUTIC DOSING AND PROGRESSION DESPITE DOSE REDUCTION.
Retin Cases Brief Rep
March 2025
Department of Ophthalmology and Visual Sciences, University of Massachusetts Chan Medical School, Worcester, MA, United States.
Purpose: To characterize evolution of deferoxamine-related retinal toxicity in a patient exposed to supratherapeutic doses of deferoxamine and progression despite dose reduction and cessation.
Methods: Observational clinical case Report.
Results: A 59-year-old female with history of beta thalassemia requiring biweekly blood transfusions developed peripheral visual field loss and nyctalopia after taking supratherapeutic dosage of deferoxamine.
Genetic, developmental, and neural changes underlying the evolution of butterfly mate preference.
PLoS Biol
March 2025
Department of Ecology & Evolution, The University of Chicago, Chicago Illinois, United States of America.
Many studies have linked genetic variation to behavior, but few connect to the intervening neural circuits that underlie the arc from sensation to action. Here, we used a combination of genome-wide association (GWA), developmental gene expression, and photoreceptor electrophysiology to investigate the architecture of mate choice behavior in Heliconius cydno butterflies, a clade where males identify preferred mates based on wing color patterns. We first found that the GWA variants most strongly associated with male mate choice were tightly linked to the gene controlling wing color in the K locus, consistent with previous mapping efforts.
View Article and Find Full Text PDFFovealNet: Advancing AI-Driven Gaze Tracking Solutions for Efficient Foveated Rendering in Virtual Reality.
IEEE Trans Vis Comput Graph
March 2025
Leveraging real-time eye tracking, foveated rendering optimizes hardware efficiency and enhances visual quality virtual reality (VR). This approach leverages eye-tracking techniques to determine where the user is looking, allowing the system to render high-resolution graphics only in the foveal region-the small area of the retina where visual acuity is highest, while the peripheral view is rendered at lower resolution. However, modern deep learning-based gaze-tracking solutions often exhibit a long-tail distribution of tracking errors, which can degrade user experience and reduce the benefits of foveated rendering by causing misalignment and decreased visual quality.
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