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http://dx.doi.org/10.1213/01.ANE.0000068983.18131.F0 | DOI Listing |
Life Sci
January 2024
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, Zhejiang Province 315211, China; Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Meishan Campus, Ningbo University, Ningbo, Zhejiang Province 315832, China. Electronic address:
Aims: Qipian® is a commercialized agent composed of extracts of three genera of commensal bacteria, and its mechanism of action on asthma is unclear. This study aimed to examine the impact of Qipian® on airway inflammation and investigate the underlying mechanisms.
Materials And Methods: Qipian® or dexamethasone (DEX) was administered before OVA challenge in an ovalbumin-induced asthma mouse model, and then asthmatic symptoms were observed and scored.
Brain
August 2023
Spinal Cord Injury Research (Neuroparaplegiology), Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
Infections are prevalent after spinal cord injury (SCI), constitute the main cause of death and are a rehabilitation confounder associated with impaired recovery. We hypothesize that SCI causes an acquired lesion-dependent (neurogenic) immune suppression as an underlying mechanism to facilitate infections. The international prospective multicentre cohort study (SCIentinel; protocol registration DRKS00000122; n = 111 patients) was designed to distinguish neurogenic from general trauma-related effects on the immune system.
View Article and Find Full Text PDFHNO
May 2023
Klinik für Hals‑, Nasen- und Ohrenheilkunde, Universitätsklinik Tübingen, Tübingen, Deutschland.
Allergic rhinitis (AR) is a very common disease with a high prevalence worldwide. It is an IgE-mediated type 2 inflammatory disease following exposure to inhalant allergens. A multitude of different neuropeptides including substance P, vasoactive intestinal peptide (VIP), calcitonin gene-related peptide (CGRP), nerve growth factor (NGF), and neuromedin U (NMU) can be released via peripheral axon or central reflexes, interact with immune cells, and thus contribute to neurogenic inflammation which causes the nasal hyperreactivity (NHR) characteristic of AR.
View Article and Find Full Text PDFCephalalgia
November 2022
Department of Neurology, Danish Headache Center, Copenhagen University Hospital, Glostrup, Denmark.
Introduction: This review aims to model migraine nociception.
Methods: Personal experience and litterature.
Results: Genetic and environmental factors in combination decide whether a person suffers from migraine.
Am J Respir Crit Care Med
September 2022
Service de Chirurgie Cardiovasculaire, Thoracique et Transplantation Pulmonaire, CHU UCL Namur and.
Donor brain death-induced lung injury may compromise graft function after transplantation. Establishing strategies to attenuate lung damage remains a challenge because the underlying mechanisms remain uncertain. The effects of tacrolimus pretreatment were evaluated in an experimental model of brain death-induced lung injury.
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