AI Article Synopsis
- Changes in enzyme activities related to adenine nucleotide hydrolysis were found in rat blood serum after prolonged stress but not after acute stress.
- In a study, male Wistar rats experienced one hour of restraint stress, and their blood serum was analyzed at various time points post-stress.
- Significant increases in hydrolysis of ATP and ADP were detected at 24 hours post-stress, while the activity of AMP hydrolysis peaked at 6 and 24 hours, suggesting potential biochemical markers for stress evaluation.
Article Abstract
Alterations of enzyme activities involved in adenine nucleotide hydrolysis have been reported in spinal cord and blood serum after repeated restraint stress. On the other hand, no effect was observed in the spinal cord of rats after acute stress. In the present study, we investigated the effect of acute stress on the hydrolysis of adenine nucleotides in rat blood serum. Adult male Wistar rats were submitted to 1-h restraint stress and were sacrificed at 0, 6, 24 and 48 h. Increased ATP and ADP hydrolysis were observed in the blood serum of stressed rats 24 h after stress (58% and 54%, respectively, when compared to controls). On the other hand, the AMP hydrolysis was increased after 6 h (68% when compared to controls) and at 24 h (94% when compared to controls) after stress. The results suggest that altered activity of soluble enzymes in serum may be a biochemical marker for stress situations.
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| http://dx.doi.org/10.1016/s0091-3057(03)00143-6 | DOI Listing |
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