In 20 patients with Stage II hypertensive disease, erythrocyte and platelet aggregation to response to ATP was photooptically studied, skin oxygen tension was polarographically examined, and the diameters of conjunctival vessels were microscopically measured. In the patients, excessive decreases in blood pressure were found to lead to lack of microvascular tone coordination, to increases in platelet and erythrocyte aggregation and to decreases in tissue oxygen supply. It was emphasized that the microcirculation and tissue oxygen supply should be monitored when clofelin dosages are chosen individually in the treatment of hypertensive disease.
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