Robust regression-based analysis of drug-nucleic acid binding.

Anal Biochem

Graduate School of Management, Kent State University, Kent, OH 44242, USA.

Published: August 2003

Outlier detection can be very important in analyzing data from Scatchard plots. In this study, a robust (outlier-resistant) regression procedure was used in conjunction with a Scatchard plot to study the binding of the methylphenazinium cation with double-stranded DNA. The procedures, their results, and their advantages are discussed.

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http://dx.doi.org/10.1016/s0003-2697(03)00290-2DOI Listing

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