Purpose: To evaluate the clinical effect of trabeculectomy combined amniotic membrane transplantation in refractory glaucoma.

Methods: Seventeen eyes of sixteen patients with uncontrolled glaucoma underwent trabeculectomy combined amniotic membrane transplantation. The mean follow-up was 11.2 months (3-24 months).

Results: The mean preoperative intraocular pressure (IOP) was (39.72 +/- 7.26) mmHg which decreased to a mean postoperative IOP of (14.62 +/- 3.72) mmHg (P < 0.001). There was an obvious diffusion blebs in each eye 3 months after the operation, there were functional blebs in 16 eyes 6 months after the operation, there were functional blebs in 14 eyes. The anterior chamber reaction was mild.

Conclusions: Trabeculectomy combined amniotic membrane transplantation is a safe and effective method for refractory glaucoma.

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