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Elucidating the role of autoreactive T cells and B cells in autoimmune hepatitis.
J Clin Invest
January 2025
How are autoreactive T cells induced and regulated in patients with autoimmune disease? This question lies at the core of understanding autoimmune disease pathologies, yet it has remained elusive due to host variability and the complexity of the immune system. In this issue of the JCI, Kramer and colleagues used autoimmune hepatitis (AIH) as a model to explore the maintenance of autoreactive CD4+ T cells specific to O-phosphoseryl-tRNA:selenocysteine tRNA synthase (SepSecS). The findings provide insight into the interaction between T cells and B cells in AIH pathogenesis that may reflect a shared mechanism among other autoimmune diseases.
View Article and Find Full Text PDFLanguage about gender/sex should be used intentionally and flexibly.
Br J Psychol
January 2025
Purdue University, West Lafayette, Indiana, USA.
In their paper, 'Conceptualizing transgender experiences in psychology: Do we have a 'true' gender?' Jackson and Bussey (British Journal of Psychology, 115, 723) critique the idea of having a 'true' gender and propose that the term 'transgender experience' may be more appropriate than 'transgender identity'. In this commentary, I reflect on the usefulness of the terms transgender identity and transgender experience and argue that both hold value and can contribute to a more nuanced discussion of gender/sex. I use the discussion of these two terms as a springboard to make a broader point: As researchers, we should use language about gender/sex flexibly and intentionally.
View Article and Find Full Text PDFThe article by Sweigart et al. presents concerns, challenges, and proposals for the current situation, both nationally and internationally, and the need for a diversity of medical care practice scenarios that simultaneously develop teaching abilities. Medical education is now conducted outside the university-affiliated teaching hospital, often in the so-called community or general hospitals dedicated to patient care.
View Article and Find Full Text PDFCommentary on "Reflections on the Inclusion of Physicians as Educators in Community Hospitals".
Rev Col Bras Cir
January 2025
- Universidade do Estado da Bahia - UNEB,, Professora Adjunta - Curso de Medicina - Departamento de Ciências da Vida - Salvador - BA - Brasil.
Addressing Unmet Needs in Eating Disorders Requires Systemic Change and Co-Production: A Commentary on Ali et al. (2024).
Int J Eat Disord
January 2025
South London and Maudsley NHS Foundation Trust, London, UK.
The treatment gap for eating disorders varies significantly across healthcare systems owing to structural, cultural, and systemic barriers. A recent systematic review by Ali et al. highlighted this disparity, with treatment rates ranging from 2.
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