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The P2X7-Mediated Mitochondrial ROS as an Emerging Core Target of Tuftsin Nanoparticles in Severe Acute Pancreatitis Therapy via Regulating Mitophagy.
ACS Appl Mater Interfaces
January 2025
Department of Gerontology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, People's Republic of China.
20% acute pancreatitis (AP) develops into severe AP (SAP), a global health crisis, with an increased mortality rate to 30%-50%. Mitochondrial damage and immune disorders are direct factors, which exacerbate the occurrence and progression of AP. So far, mitochondrial and immunity injury in SAP remains largely elusive, with no established treatment options available.
View Article and Find Full Text PDFFollicular lymphoma (FL) outcomes are heavily influenced by host immune activity with immune anti-tumor activity mitigated by PD-1/PD-L1 pathway engagement. Combination CD20-directed therapy plus PD-1 inhibition (PD-1i) increases T-cell tumor killing and NK-cell antibody-dependent cell cytotoxicity (ADCC). Mounting evidence supports immune-priming using PD-1i before cancer-directed agents.
View Article and Find Full Text PDFMachine Learning-Guided Fluid Resuscitation for Acute Pancreatitis Improves Outcomes.
Clin Transl Gastroenterol
January 2025
Division of Gastroenterology, Department of Medicine.
Objectives: Ariel Dynamic Acute Pancreatitis Tracker (ADAPT) is an artificial intelligence tool using mathematical algorithms to predict severity and manage fluid resuscitation needs based on the physiologic parameters of individual patients. Our aim was to assess whether adherence to ADAPT fluid recommendations versus standard management impacted clinical outcomes in a large prospective cohort.
Method: We analyzed patients consecutively admitted to the Los Angeles General Medical Center between June 2015 to November 2022 whose course was richly characterized by capturing more than 100 clinical variables.
Construction of a Multi-View Deep Learning Model for the Severity Classification of Acute Pancreatitis.
Discov Med
January 2025
Department of General Surgery, First Affiliated Hospital of Dalian Medical University, 116011 Dalian, Liaoning, China.
Background: Acute pancreatitis (AP) is a prevalent pathological condition of abdomen characterized by sudden onset, high incidence and complex progression. Timely assessment of AP severity is crucial for informing intervention decisions so as to delay deterioration and reduce mortality rates. Existing AP-related scoring systems can only assess current condition of patients and utilize only a single type of clinical data, which is of great limitation.
View Article and Find Full Text PDFGLP-1 receptor agonists in diabetes and weight loss: the double-edged sword of innovation and risks.
Front Clin Diabetes Healthc
January 2025
School of Medicine, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (Promise), University of Palermo, Palermo, Italy.
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