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Immunoregulation of hapten and drug induced immune reactions. | LitMetric

Immunoregulation of hapten and drug induced immune reactions.

Curr Opin Allergy Clin Immunol

Laboratory of Immunology, Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy.

Published: August 2003

AI Article Synopsis

  • The review discusses how unbalanced immune responses to haptens can lead to diseases like allergic contact dermatitis and drug-induced immune reactions.
  • It highlights recent findings that specific regulatory T cell subsets, such as T regulatory cell 1-like cells and CD4+CD25+ cells, can suppress immune reactions to haptens, like nickel.
  • The authors emphasize the need for more research on these regulatory T cells, particularly in relation to drug hypersensitivity, as their understanding could help develop better desensitization treatments.

Article Abstract

Purpose Of Review: Unbalanced immune responses to haptens lead to a variety of diseases, including allergic contact dermatitis to skin sensitizers and drug induced immune reactions. The occurrence, magnitude and persistence of immune responses are modulated by specialized T cell subsets with regulatory function. The purpose of this brief review is to summarize the recent data on the role of regulatory T cells in the control of hapten mediated diseases.

Recent Findings: Several subsets of regulatory T cells, including T regulatory cell 1-like lymphocytes, and cutaneous lymphocyte associated antigen+ CD4+CD25+ regulatory T cells have been isolated from the skin at sites of hapten challenge. Both cell types suppress specific T cell responses to cutaneous sensitizers, such as nickel.

Summary: Although data concerning the regulation of drug hypersensitivity are lacking, several reports indicate the role of regulatory T cell subsets in allergic contact dermatitis to haptens. The understanding of their role in hapten diseases and the requirement for their in-vivo and in-vitro expansion appears as a critical step for the development of specific desensitization protocols.

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Source
http://dx.doi.org/10.1097/00130832-200308000-00002DOI Listing

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