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Prolonged Copper Supplementation Modified Minerals in the Kidney, Liver and Blood, and Potentiated Oxidative Stress and Vasodilation of Isolated Aortic Rings in Young Wistar Rats.
Nutrients
September 2024
Department of Pharmacology and Toxicology, Faculty of Medicine, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.
Background: Previous studies have highlighted that copper supplementation at 200% of the recommended daily dietary allowance modified vascular contraction and relaxation through increased reactive oxygen species (ROS) and prostaglandin formation, which modified the antioxidant status of middle-aged Wistar rats.
Methods: In this study, young (1 month old) male Wistar rats (/group = 10) received a diet supplemented with 6.45 mg copper/kg (100% of daily recommendation-Group A) for 8 weeks.
Microglia mitochondrial complex I deficiency during development induces glial dysfunction and early lethality.
Nat Metab
August 2024
Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
Primary mitochondrial diseases (PMDs) are associated with pediatric neurological disorders and are traditionally related to oxidative phosphorylation system (OXPHOS) defects in neurons. Interestingly, both PMD mouse models and patients with PMD show gliosis, and pharmacological depletion of microglia, the innate immune cells of the brain, ameliorates multiple symptoms in a mouse model. Given that microglia activation correlates with the expression of OXPHOS genes, we studied whether OXPHOS deficits in microglia may contribute to PMDs.
View Article and Find Full Text PDFPrimary diffuse large B-cell lymphoma of adrenal gland: A case report.
Medicine (Baltimore)
June 2024
Department of Urology, Xichang People's Hospital, Xichang, Sichuan, P.R. China.
Article Synopsis
- Most adrenal tumors are benign, but primary adrenal lymphoma (PAL) is a rare and aggressive type of cancer that is difficult to diagnose and has a poor prognosis.
- The case report describes a 42-year-old woman with a large adrenal tumor that exhibited symptoms like abdominal pain and was initially suspected to be pheochromocytoma, but turned out to be lymphoma after surgery.
- The findings suggest that primary adrenal diffuse large B-cell lymphoma (PADLBCL) should be considered in patients with large adrenal masses, and that chemotherapy prior to surgery could improve treatment outcomes and patient survival quality.
Age-related changes in P2Y receptor signalling in mouse cochlear supporting cells.
J Physiol
October 2023
School of Biosciences, University of Sheffield, Sheffield, UK.
Our sense of hearing depends on the function of a specialised class of sensory cells, the hair cells, which are found in the organ of Corti of the mammalian cochlea. The unique physiological environment in which these cells operate is maintained by a syncitium of non-sensory supporting cells, which are crucial for regulating cochlear physiology and metabolic homeostasis. Despite their importance for cochlear function, the role of these supporting cells in age-related hearing loss, the most common sensory deficit in the elderly, is poorly understood.
View Article and Find Full Text PDFSleep quality and temperament in association with autism spectrum disorder among infants in Japan.
Commun Med (Lond)
June 2023
Regional Center for Japan Environment and Children's Study, University of Occupational and Environmental Health, Kitakyushu, Japan.
Article Synopsis
- This study explores the link between sleep problems and irritability in 1-month-old infants and the subsequent development of autism spectrum disorder (ASD) by the age of 3.
- Using data from over 69,000 participants, the researchers found longer daytime sleep and intense crying are associated with a higher risk of developing ASD.
- Notably, the findings suggest that female infants with poor temperaments are at an even greater risk for ASD, highlighting the need for targeted interventions.
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