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Aseptic Meningitis and White Matter Disease in Childhood-Onset Neuropsychiatric Lupus.
Case Rep Rheumatol
December 2024
Department of Paediatrics, Queen Elizabeth Hospital, 30 Gascoigne Road, King's Park, Hong Kong.
We reported a 10-year-old girl who had an atypical demyelinating disease as the presentation of her neuropsychiatric lupus. The patient had a 4-year history of systemic lupus erythematosus which had been on remission until she presented with fever and headache at the age of 10 years. Physical examination showed meningism.
View Article and Find Full Text PDFRecurrent aseptic abscesses resulting in superficial pyoderma gangrenosum-like ulcers in a patient with granulomatosis with polyangiitis.
Dermatol Online J
October 2024
Department of Dermatology, Fukushima Medical University, Fukushima, Japan.
Patients with granulomatosis with polyangiitis occasionally present with cutaneous manifestations, which are important clues for the early diagnosis. Although pyoderma gangrenosum-like ulcers are rarely observed, a unique case with unusual clinical features is presented herein. A 75-year-old woman with positive proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA) repeatedly developed aseptic abscesses on the abdomen, buttock, lower legs, and forearms.
View Article and Find Full Text PDFTranscriptomic analysis of coxsackievirus B3 infection in induced pluripotent stem cell-derived brain-like endothelial cells.
J Virol
December 2024
Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama, USA.
Unlabelled: Viral aseptic meningitis is a neuroinflammatory condition that occurs when viruses gain access to the central nervous system (CNS) and induce inflammation. The blood-brain barrier (BBB) is comprised of brain endothelial cells (BECs) that stringently regulate the passage of molecules, toxins, and pathogens from the circulation into the CNS. Through their unique properties, such as complex tight junctions, reduced rates of endocytosis, expression of efflux transporters, and restricted expression of leukocyte adhesion molecules, the BBB is often able to limit pathogen entry into the brain; however, certain neurotropic pathogens, such as coxsackievirus B3 (CVB3) are able to infect the CNS.
View Article and Find Full Text PDFOrbital Cellulitis Complicated by Cerebral Vein Thrombosis and Meningitis in a Young, Healthy Adult.
Cureus
October 2024
Internal Medicine, Jackson Memorial Hospital, Miami, USA.
Orbital cellulitis is a serious infection that can lead to severe complications if not promptly diagnosed and treated. This case report describes an unusual presentation of bilateral orbital cellulitis in a previously healthy 29-year-old female, complicated by cerebral vein thrombosis and meningitis. The patient's young age and lack of significant medical history make this case particularly noteworthy.
View Article and Find Full Text PDFLeptomeningeal Disease Secondary to Invasive Ductal Carcinoma of the Breast: A Rapidly Progressive and Fatal Complication.
Cureus
November 2024
Internal Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, GBR.
Leptomeningeal disease (LMD) is a rare yet serious complication of advanced malignancy, often seen in breast cancer and associated with a poor prognosis. This case report highlights the rapid progression and diagnostic challenges encountered in a woman in her 40s with advanced breast cancer who presented with severe headaches, absence seizures, and diplopia. The patient's complex past history included invasive ductal carcinoma, prior brain metastasis, and recent craniotomy, which added significant challenges to diagnosis and management.
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