Objective: To establish a HPLC method for determining the content of free salicylic acid in chewing aspirin tablets.
Method: The determination was conducted on a HPLC column (C(18), 150 mm x 4.6 mm x 5 microm) with methanol-water-glacial acetic acid (8.0 5.5 1.0) as the mobile phase and the detection wavelength of 302 nm.
Results: The calibration curve was linear within the concentration range of 2.65 to 31.77 microg/ml (r=0.999 97) of salicylic acid. The average recovery rate was 100.21% with relative standard deviation of 0.53% (n=6).
Conclusion: HPLC is quick and accurate of determining the content of free salicylic acid for chewing aspirin tablets.
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