Aim: To identify the prevalence of drug misuse (illicit, over-the-counter and prescribed) by patients at Bristol Royal Infirmary, an inner-city teaching hospital, and the problems encountered by ward staff in the management of these patients.
Method: A prevalence survey was conducted in the A&E department of the hospital using an adapted version of the two-item conjoint screening test (TICS), a validated screening tool devised by Brown et al (1997). A qualitative survey of ward managers was used to identify the problems presented by drug misusers on the ward, and to gather suggestions for the role of a specialist substance misuse liaison worker.
Results: An 11 per cent prevalence of drug misuse was found among 64 patients attending the A&E department. In the survey of 18 ward managers, ten (55.5 per cent) wards admitted a minimum of one drug misuser each week and 15 wards (83 per cent) described negative behaviours among this patient group which had an effect on the management of the ward.
Conclusion: Consideration should be given to routine screening for the presence of drug misuse among patients. Introduction of a specialist drug misuse liaison worker and guidelines for the management of this patient group would help to reduce the significant problems experienced by staff.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.7748/ns2003.06.17.41.33.c3410 | DOI Listing |
J Neuroimmunol
January 2025
Immunology Laboratory, Department of Biomedical Engineering, Indian Institute of Technology Ropar, Rupnagar 140001, Punjab, India. Electronic address:
Morphine is a globally prevalent substance of misuse, renowned for its immunosuppressive effects mediated through opioid receptors expressed on immune cells. Macrophages are crucial antigen-presenting cells that fulfill diverse roles, such as antigen presentation, phagocytosis, wound healing, and disease protection. They are typically classified based on their activation states: M1 (proinflammatory), M2 (anti-inflammatory), and M0 (resting).
View Article and Find Full Text PDFTher Adv Drug Saf
January 2025
Pharmacology Department, School of Medicine, University of Valladolid, Valladolid, Spain.
In 2019, intranasal esketamine gained approval as a promising therapy for those individuals grappling with treatment-resistant depression. Both clinical trials and real-world studies have underscored its efficacy in alleviating and remitting depressive symptoms, with sustained benefits observed for nearly 4.5 years.
View Article and Find Full Text PDFFront Microbiol
January 2025
Department of Comparative Biomedicine and Food Science, University of Padua, Legnaro, Italy.
Introduction: Poultry production accounts for 42% of Cameroonian meat production. However, infectious diseases represent the main hindrance in this sector, resulting in overuse and misuse of antimicrobials that can contribute to the emergence and dissemination of antimicrobial resistance (AMR). This study aimed to evaluate the prevalence of antimicrobial resistance genes (ARGs) conferring resistance to carbapenems ( and ), (fluoro) quinolones (, , and ), polymyxins ( to ), and macrolides ( and ) in the poultry farm environment.
View Article and Find Full Text PDFJ Pharm Biomed Anal
January 2025
Jožef Stefan Institute, Jamova 39, Ljubljana 1000, Slovenia; Jožef Stefan International Postgraduate School, Jamova 39, Ljubljana 1000, Slovenia. Electronic address:
Wastewater-based epidemiology (WBE) offers a promising approach by providing objective data on antipsychotic drug consumption within a population that can be used to monitor abuse, misuse, and regional prescription patterns. However, accurate estimations depend on knowing the stability of drug biomarkers. This study provides a comprehensive analysis of the stability of 11 antipsychotic biomarkers (parent drugs and their metabolites) in influent wastewater, using a series of experiments mimicking in-sewer transport (in-sewer setup and deconjugation) and in-sample stability (benchtop, frozen cartridge, long-term sample storage, and freeze-thaw).
View Article and Find Full Text PDFAIDS
March 2025
Faculty of Health Sciences, Simon Fraser University, Burnaby.
The breadth of the overdose crisis is underestimated because of a lack of quantifying nonfatal overdoses. We estimate the proportion of nonfatal overdoses among all people with HIV (PWH) in British Columbia, Canada, and the prevalence of fatal overdoses among people who had a nonfatal overdose, stratified by sex. A small proportion of PWH who experienced a nonfatal overdose subsequently died of a fatal overdose, signaling opportunities for crucial interventions and treatment to prevent overdose death.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!