Nitric oxide (NO) and obstructive sleep apnea are inseparable. Obstructive sleep apnea could be described as the intermittent failure to transport the full complement of nasal NO to the lung with each breath. There NO matches perfusion to ventilation. NO is utilized by the efferent pathways that control the unequal, inspiratory battle between the pharyngeal dilators and the closing negative pressures induced by the thoracic musculature. Recurrent cortical arousals are a major short-term complication, and the return to sleep after each arousal uses NO. The long-term complications, namely hypertension, myocardial infarction, and stroke, might be due to the repeated temporary dearth of NO in the tissues, secondary to a lack of oxygen, one of NO's two essential substrates.
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http://dx.doi.org/10.1007/s11325-003-0053-4 | DOI Listing |
Am J Respir Crit Care Med
January 2025
Beth Israel Deaconess Medical Center, Pulmonary, Critical Care and Sleep Medicine, Boston, Massachusetts, United States.
Radiol Cardiothorac Imaging
February 2025
From the Department of Biomedical Engineering (X.Z.) and Columbia Magnetic Resonance Research Center (CMRRC) (W.S.), Columbia University, New York, NY; Departments of Medicine (C.B.C., J.P.F.) and Radiology (J.P.F.), University of California at Los Angeles, Los Angeles, Calif; Department of Radiology, Weill Cornell Medicine, New York, NY (M.R.P.); Department of Radiology (M.R.P., S.M.D., S.J.), Department of Medicine (M.C.B., R.G.B.), Department of Epidemiology (R.G.B.), Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics (W.S.), and Institute of Human Nutrition (W.S.), Columbia University Irving Medical Center, 632 W 168th St, PH-17, New York, NY 10032; Department of Radiology (B.A.V., J.A.C.L.) and Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine (N.N.H.), Johns Hopkins University, Baltimore, Md; Department of Radiology, University of Michigan, Ann Arbor, Mich (P.P.A.); Department of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wis (D.A.B.); Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC (D.C.); Departments of Radiology, Medicine, and the Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa (E.A.H.); Sections on Cardiology and Geriatrics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC (D.W.K.); Division of Pulmonary, Critical Care, Sleep, and Allergy (J.A.K.) and Department of Radiology, College of Medicine (M.G.M.), University of Illinois at Chicago, Chicago, Ill; Department of Radiology and Biomedical Imaging (Y.J.L., J.L.), Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, School of Medicine (P.G.W.), and Cardiovascular Research Institute (P.G.W.), University of California at San Francisco, San Francisco, Calif; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Wake Forest University, Winston-Salem, NC (J.O., S.P.P.); Division of Pulmonary Medicine, Department of Medicine, Mayo Clinic, Phoenix, Ariz (V.E.O.); Department of Medicine, University of Utah, Salt Lake City, Utah (R.P.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.D.S.); Department of Radiology, Hannover Medical School, Hannover, Germany (J.V.C.); and BREATH, Member of the German Center for Lung Research (DZL), Hannover, Germany (J.V.C.).
Purpose To assess the repeatability of real-time cine pulmonary MRI measures of metronome-paced tachypnea (MPT)-induced dynamic hyperinflation and its relationship with chronic obstructive pulmonary disease (COPD) severity. Materials and Methods SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS) (ClinicalTrials.gov identifier no.
View Article and Find Full Text PDFClin Otolaryngol
January 2025
Department of Otorhinolaryngology-Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Introduction: Obstructive sleep apnoea (OSA) in children is associated with numerous adverse outcomes, including elevated blood pressure. While the associations between OSA, obesity, and autonomic dysfunction are recognised, the precise mechanisms linking these factors and their relationship with elevated blood pressure in children remain unclear.
Methods: This retrospective case series included 76 children with OSA.
Pediatr Obes
January 2025
Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Objectives: To investigate the association of sleep-disordered breathing (SDB) severity with cardiometabolic and inflammatory markers independently of the adiposity levels; and to explore the role of cardiorespiratory fitness in these associations in children with overweight/obesity.
Methods: A total of 109 children aged 8-11 years with overweight/obesity were included in this cross-sectional study. SDB was assessed using a scale of the reduce version of the Paediatric Sleep Questionnaire.
Front Cell Neurosci
January 2025
Laboratory of Human Anatomy, Department of Experimental Medicine, University of the Salento, Lecce, Italy.
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