Objective: Dramatic improvements in clinical symptoms of rheumatoid arthritis and ulcerative colitis were observed after patients received granulocyte and monocyte adsorptive apheresis with a column containing cellulose acetate (CA) beads as adsorptive carriers. This study was to investigate the effect of CA beads on the generation of anti-inflammatory and pro-inflammatory cytokines in human blood.
Materials And Methods: We incubated human whole blood with CA beads at 37 degrees C for up to 2 h and measured tumour necrosis factor-alpha (TNF-alpha) interleukin-1beta (IL-1beta) and IL-1 receptor antagonist (IL-1ra) produced by leucocytes. IL-1ra was also measured at the inflow and outflow of a column containing CA beads as leucocyte adsorptive carriers for the treatment of patients with ulcerative colitis.
Results: CA beads induced significant release of IL-1ra from leucocytes, but not TNF-alpha or IL-1beta. In contrast, all three cytokines were released when leucocytes were stimulated with lipopolysaccharide. IL-1ra was also markedly elevated in the outflow of the leucocyte apheresis column.
Conclusions: These results indicate that CA beads selectively induce IL-1ra release from leucocytes which should contribute to the anti-inflammatory effect of granulocyte and monocyte adsorptive apheresis with CA beads as apheresis carriers.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00011-003-1173-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhancing Periodontal Ligament Regeneration via PDLSC Delivery Using Electrospun PCL/Collagen/Cellulose Acetate Scaffolds and Collagen Hydrogel Incorporated with Curcumin-Loaded ZIF-8 Nanoparticles.
Int J Nanomedicine
January 2025
Department of Stomatology, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China.
Background: Regenerating periodontal ligament (PDL) tissue is a vital challenge in dentistry that aims to restore periodontal function and aesthetics. This study explores a tissue engineering strategy that combines polycaprolactone (PCL)/collagen/cellulose acetate electrospun scaffolds with collagen hydrogels to deliver curcumin-loaded ZIF-8 nanoparticles fand periodontal ligament stem cells (PDLSCs).
Methods: Scaffolds were fabricated via electrospinningand collagen hydrogels incorporated PDLSCs and curcumin-loaded ZIF-8 nanoparticles (CURZIF-8) were developed using cross-linking.
Improving CO Removal Efficiency with Bio-Cellulose Acetate: A Multi-Stage Membrane Separation Approach.
Polymers (Basel)
January 2025
Biomass and Oil Palm Research Center of Excellence, Walailak University, Thasala, Nakhon Si Thammarat 80160, Thailand.
In this comprehensive investigation, the sustainable production and utilization of gas separation membranes derived from coconut water (CW) waste was investigated. The research focuses on the synthesis of bacterial cellulose (BC) and cellulose acetate (CA) membranes from CW, followed by a thorough analysis of their characteristics, including morphology, ATR-FTIR spectroscopy, tensile strength, and chemical composition. The study rigorously evaluates membrane performance, with particular emphasis on CO/CH selectivity under various operational conditions, including pressure, membrane thickness, and number of stages.
View Article and Find Full Text PDFImproved Biomineralization Using Cellulose Acetate/Magnetic Nanoparticles Composite Membranes.
Polymers (Basel)
January 2025
Department of Dental Medicine and Nursing, Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.
Following implantation, infections, inflammatory reactions, corrosion, mismatches in the elastic modulus, stress shielding and excessive wear are the most frequent reasons for orthopedic implant failure. Natural polymer-based coatings showed especially good results in achieving better cell attachment, growth and tissue-implant integration, and it was found that the inclusions of nanosized fillers in the coating structure improves biomineralization and consequently implant osseointegration, as the nanoparticles represent calcium phosphate nucleation centers and lead to the deposition of highly organized hydroxyapatite crystallites on the implant surface. In this study, magnetic nanoparticles synthesized by the co-precipitation method were used for the preparation of cellulose acetate composite coatings through the phase-inversion method.
View Article and Find Full Text PDFEfficient and accurate determination of the degree of substitution of cellulose acetate using ATR-FTIR spectroscopy and machine learning.
Sci Rep
January 2025
Institute of Biological and Chemical Systems - Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Karlsruhe, 76344, Germany.
Multiple linear regression models were trained to predict the degree of substitution (DS) of cellulose acetate based on raw infrared (IR) spectroscopic data. A repeated k-fold cross validation ensured unbiased assessment of model accuracy. Using the DS obtained from H NMR data as reference, the machine learning model achieved a mean absolute error (MAE) of 0.
View Article and Find Full Text PDFAntibacterial food packaging using biocompatible nickel oxide-infused cellulose acetate electrospun nanofibers.
Food Chem
January 2025
Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India.
The present study included the environmentally friendly production of stable nickel nanoparticles (NiO NPs) using lemon and tomato, followed by their analysis and evaluation for their antibacterial properties against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Bacillus cereus. The Nickel oxide nanoparticles produced exhibited their maximum absorption at 276 nm in the UV-vis spectrum. The image captured FESEM revealed smooth nanofibers with an average diameter of around 259 ± 3.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!