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| http://dx.doi.org/10.1073/pnas.1633688100 | DOI Listing |
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Hydrogen-deuterium exchange mass spectrometry (HDX-MS) approach has become a valuable analytical complement to traditional methods. HDX-MS allows the identification of dynamic surfaces in proteins. We have shown that the introduction of various mutations into the amino acid sequence of whale apomyoglobin (apoMb) leads to a change in the number of exchangeable hydrogen atoms, which is associated with a change in its compactness in the native-like condition.
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School of Tourism and Cuisine, Yangzhou University, Yangzhou 225127, China; Key Laboratory of Chinese Cuisine Intangible Cultural Heritage Technology Inheritance, Ministry of Culture and Tourism, Yangzhou, China. Electronic address:
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View Article and Find Full Text PDFSpectroscopy-based analysis of the effect of Maillard reaction products on oxidative stability of carp myoglobin.
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College of Food Science, Shenyang Agricultural University, Shenyang, Liaoning, China.
As a pro-oxidant, myoglobin (Mb) can induce lipid oxidation in meat. In this study, Fourier-transform infrared spectroscopy (FTIR), circular dichroism (CD), fluorescence spectroscopy, UV-vis spectrophotometry, and fluorescence microscopy were used to evaluate the impact of Maillard reaction products (MRPs) formed from glucose and lysine on the oxidative stability of carp Mb. MRPs were found to inhibit the auto-oxidation of Mb, reducing MetMb production by 8.
View Article and Find Full Text PDFThe role of proton-coupled electron transfer from protein to heme in dehaloperoxidase.
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Department of Chemistry, North Carolina State University, Raleigh, NC 27695, United States of America. Electronic address:
At least two of the six methionine (Met) residues in dehaloperoxidase (DHP) are shown to act as electron donors in both autoreduction and protein-heme crosslinking. Autoreduction observed in the two isozymes, DHP-A and DHP-B, is explained by the high heme reduction potential and an endogenous source of electrons from methionine (Met) or cysteine (Cys). This study provides evidence of a connection to protein-heme crosslinking that occurs when DHP is activated by HO in competition with substrate oxidation and autoreduction.
View Article and Find Full Text PDFExperimental and Numerical Integrated Strategy for the Optimization of Microfluidic Parameters for Eudragit L100 Nanoparticles and Microparticles.
Mol Pharm
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Department of Drug Sciences, University of Pavia, V.le Taramelli 12, Pavia 27100, Italy.
Oral immunization offers a minimally invasive administration, inducing local and systemic immune responses and facilitating mass immunization without needle-related risks. However, the gastrointestinal environment poses challenges, compromising vaccine effectiveness through enzymatic degradation and poor absorption by Peyer's patches. Advances in nanoparticle and microparticle (NP/MP) technology protect vaccines from degradation and enhance targeted release.
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