AI Article Synopsis
- The study investigates how differentiation of colon carcinoma CT26 cells affects the accumulation of photosensitizers used in photodynamic therapy (PDT).
- Significant morphological and protein expression changes were observed in differentiated cells, which correlated with different levels of photosensitizer accumulation.
- The findings suggest that poorly differentiated tumors tend to accumulate specific photosensitizers more effectively, potentially enhancing their suitability for photo-diagnostic applications in PDT.
Article Abstract
The relationship between tumor cell differentiation and photosensitizer accumulation used in PDT is poorly defined. In the present work, specific cell differentiation of colon carcinoma CT26 cells induced by sodium butyrate was manifested by morphological changes, proliferation and protein expression and was correlated with the accumulation of endogenous and exogenous photosensitizes. Reduced accumulation of the endogenous protoporphyrin IX and the exogenous hypericin and MC540 was detected in differentiated cells. In contrast, a differentiation-dependent increase was measured with TPPS4, TMPyP, the pheophorbides (C5, C6, C12), HypS4 and helianthrone. In conclusion, PpIX, Hypericin and MC540 show specific binding and accumulation in poorly differentiated tumors, giving these tumors tissue-specific advantage in photo-diagnostic PDT applications.
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| http://dx.doi.org/10.1016/s0304-3835(03)00207-6 | DOI Listing |
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