AI Article Synopsis
- Calcium-permeable glutamate receptors are believed to play a crucial role in neuronal death after brain injuries and diseases like stroke and neurodegeneration.
- Cobalt uptake can serve as an indicator for these receptors, but the specific contributions of AMPA and kainate receptors, as well as the effect of receptor desensitization, need further investigation.
- The study found that selectively activating AMPA receptors without desensitization effectively promoted Co2+ staining, while kainate receptor activation did not lead to this staining, indicating a targeted mechanism in rat hippocampal neurons.
Article Abstract
Activation of calcium permeable glutamate receptors is likely to be important for neuronal death associated with brain trauma, stroke and neurodegenerative diseases. Cobalt uptake can be used to identify cells containing Ca2+-permeable non-NMDA ionotropic glutamate receptors. However, the relative contribution of AMPA and kainate receptors, and also the role of receptor desensitization on the influx of Co2+, remain to be established. We found that the selective non-desensitizing activation of AMPA receptors was efficient in promoting Co2+ staining. However, the selective activation of kainate receptors, even under non-desensitizing conditions, did not result in Co2+ staining. Taken together, our results show that non-desensitizing stimulation of AMPA, but not of kainate receptors, mediates the influx of Co2+ in cultured rat hippocampal neurons.
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| http://dx.doi.org/10.1097/00001756-200305060-00014 | DOI Listing |
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