A mu-class glutathione S-transferase (Cs26GST) of molecular mass 26 kDa was characterized from Clonorchis sinensis. In adult C. sinensis, the distribution of the Cs26GST was investigated by immuno-histochemistry and electron microscopy. Cs26GST was localized to the tegument and parenchyma. Immunogold labeling was strong in the tegumental cell bodies and moderate in the tegument and ova in the oviduct. It is suggested that Cs26GST plays a role in the metabolism and fecundity of C. sinensis.
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http://dx.doi.org/10.1016/s0014-4894(03)00056-0 | DOI Listing |
Microbiol Spectr
December 2024
Department of Cell Biology and Genetics, School of Basic Medical Sciences, Guangxi Medical University, Nanning, China.
Unlabelled: remains a non-negligible global zoonosis, imposing serious socio-economic burdens in endemic regions. The interplay between gut microbiota and the host transcriptome is crucial for maintaining health; however, the impact of juvenile infection on these factors is still poorly understood. This study aimed to investigate their relationship and potential pathogenic mechanisms.
View Article and Find Full Text PDFTrans R Soc Trop Med Hyg
December 2024
Department of Medical Statistics, School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Road, 510080, Yuexiu District, Guangzhou, Guangdong Province, People's Republic of China.
Background: Cognition, behaviours and social environment are associated with Clonorchis sinensis infection, a prevalent liver fluke disease in China. This study aimed to use social cognitive theory (SCT) to investigate these three aspects and their interaction in an endemic area.
Methods: We conducted three semi-structured focus group discussions in Da'ao town, Jiangmen city, Guangdong Province, China.
Parasitol Res
December 2024
Department of Medical Sciences, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Clonorchiosis, a disease that develops following the consumption of raw freshwater fish that harbors Clonorchis sinensis metacercariae, seriously threatens the health of residents in endemic areas. We aimed to assess the level of awareness of liver fluke infections among infected residents and restaurant workers in liver fluke infection-endemic areas. To identify and provide a more realistic description of C.
View Article and Find Full Text PDFPLoS Negl Trop Dis
December 2024
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (ICG SB RAS), Novosibirsk, Russia.
Background: Epidemiologically important food-borne trematodes Opisthorchis viverrini and Clonorchis sinensis are recognized as biological carcinogens of Group 1A, while Opisthorchis felineus is in Group 3 as noncarcinogenic to humans. Mechanisms of the biological carcinogenesis are still elusive. Some studies highlight chronic inflammation as a key factor and common pathway for cancer initiation and progression.
View Article and Find Full Text PDFPLoS One
December 2024
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (ICG SB RAS), Novosibirsk, Russia.
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