We report in detail an experience with irreversible interstitial pneumonitis developed during gold sodium thiomalate therapy. Factors that could influence the unfavourable course of this adverse, usually reversible pharmacological reaction, are analysed, and the importance of early recognition and prompt discontinuation of the drug is emphasised.
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Fatal, gold-induced pneumonitis.
Rheumatol Int
July 2003
Servicio de Neumologia, Hospital General Universitario, Alicante, Spain.
We report in detail an experience with irreversible interstitial pneumonitis developed during gold sodium thiomalate therapy. Factors that could influence the unfavourable course of this adverse, usually reversible pharmacological reaction, are analysed, and the importance of early recognition and prompt discontinuation of the drug is emphasised.
View Article and Find Full Text PDFGold-induced aplastic anemia.
Clin Rheumatol
December 1987
Department of Rheumatology, Algemeen Ziekenhuis Middelheim, Antwerpen, Belgium.
Three patients receiving gold salt treatment for rheumatoid arthritis developed severe aplastic anemia. All three patients experienced remission of their disease at the time of the occurrence of marrow aplasia. Reviewing data on these patients and recent literature indicate that fatal marrow aplasia seems to occur more frequently in sero-negative women who respond well to therapy with gold salts.
View Article and Find Full Text PDFThe case of a 33-year-old female patient with rheumatoid arthritis who developed a severe pulmonary fibrosis during chrysotherapy of 3.5 months' duration is reported. The course of the fibrosis was progressive and led to respiratory insufficiency and death.
View Article and Find Full Text PDFNonexudative diarrhea after gold salt therapy: case report and review of the literature.
Am J Gastroenterol
January 1983
A case of fulminant watery diarrhea after therapy with 485 mg of gold thioglucose in a 78-yr-old woman suffering from rheumatoid arthritis is presented. Evaluation failed to reveal evidence of infection, malabsorption, or mucosal inflammation. Treatment, after stopping therapy, was supportive over several months and the patient recovered completely.
View Article and Find Full Text PDFA case of gold-induced aplastic anemia occurring in a 58-year-old male with rheumatoid arthritis who received a total dose of 635 mg of gold sodium thiomalate over a 16-week period is reported. The clinical features, treatment, prevention and pathogenesis of gold-induced aplastic anemia are reviewed. The ability to predict patients in whom this hematologic effect may occur is discussed.
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