Some theories implicate abnormal self-schemas in the development of psychosis in general and in paranoid delusions in particular. Patients with delusions may also be highly intolerant of ambiguity. No study has yet compared remitted and currently ill paranoid patients on schema measures, or on tolerance of ambiguity. Currently ill psychotic patients with persecutory delusions, patients whose persecutory delusions had remitted, and normal participants completed the Personal Style Inventory (PSI), a self-schema measure, and the Need for Closure Scale (NCS), a measure of intolerance of ambiguity. Acutely ill patients scored higher than normal participants on the PSI autonomy scale. This difference became nonsignificant when depression was included as a covariate. Ill and remitted patients scored higher than normal participants on the NCS. This difference could not be explained entirely by comorbid depression. Currently paranoid and remitted paranoid patients are highly intolerant of ambiguity. It is possible that this contributes to their performance on reasoning measures. The role of self-schemas in paranoid thinking needs to be studied further.
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http://dx.doi.org/10.1348/147608303765951195 | DOI Listing |
Schizophr Bull
January 2025
Clinical, Educational and Health Psychology, University College London, London, WC1E 6BT, UK.
Background And Hypothesis: Delusions are classified into themes but the range of themes reported in the literature has never been examined and the extent to which they differ in prevalence, or relate to clinical characteristics or cultural variation, remains poorly understood.
Study Design: We identified studies reporting delusional theme prevalence in adults with psychosis and completed two multivariate, multilevel, random-effects meta-analyses: one including data from structured assessment scales only and another also including data from ad hoc and clinical assessments to include themes from a wider range of countries and contexts. Sensitivity and meta-regression analyses examined the association with clinical and methodological variables.
J Community Hosp Intern Med Perspect
November 2024
Department of Medicine, Georgetown University School of Medicine, Washington DC, USA.
Neurosyphilis is a condition characterized by insidious onset of encephalopathy and delirium. The infrequency with which it is encountered makes neurosyphilis a formidable diagnostic challenge. We present a rare case of a 71-year-old male with ischemic cardiomyopathy, chronic obstructive pulmonary disease (COPD), undifferentiated arthritis and alcohol use disorder who was brought to the emergency department after he was found altered, confused, and paranoid.
View Article and Find Full Text PDFSurg Neurol Int
December 2024
Department of Neurosurgery, Fundación Clínica Shaio, Bogotá, Colombia.
Background: Impulsive aggression is the core symptom of intermittent explosive disorder, which can be a feature of several psychiatric disorders. There is a subset of individuals who do not respond adequately to medical treatment; they are treatment refractory. The objective of this report is to describe a case of a patient with a background of schizophrenia and concomitant refractory aggressiveness disorder, treated with two-stage bilateral hypothalamotomy and unilateral amygdalotomy with Gamma Knife radiosurgery (GKR).
View Article and Find Full Text PDFChin J Integr Med
January 2025
Department of Acupuncture and Moxibustion, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100007, China.
Objective: To explore the effects of acupuncture in comparison with sham acupuncture on cognitive functions in patients with relapsing-remitting multiple sclerosis (RRMS).
Methods: In this randomized controlled trial, 31 RRMS patients in the acupuncture group were treated with traditional Chinese acupuncture based on the treatment principle of calming the mind, reinforcing qi and blood, and 31 patients in the control group were treated with sham acupuncture (shallow needling at non-acupuncture points) twice a week for 12 weeks. The primary outcome was the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) score, which was evaluated by a psychologist at baseline and after 12 weeks of treatment.
Cureus
November 2024
Psychiatry, Maudsley Health, Al Amal Psychiatric Hospital, Dubai, ARE.
Schizophrenia is a chronic psychiatric disorder marked by severe disturbances in thought, perception, and behavior. Long-acting injectable (LAI) antipsychotics, such as paliperidone, are widely used to promote sustained remission and ensure medication adherence, especially in patients prone to relapse. However, the COVID-19 pandemic has introduced unique challenges, with studies indicating that infections like COVID-19 may exacerbate psychiatric symptoms through neuroinflammatory pathways.
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