Visuo-motor coordination is normal in patients with major depression.

Depression and Parkinson's disease (PD) are strongly associated with each other. Similarly, deficient visuo-motor coordination (VMC) accompanies PD from its earliest clinical stages. This double association suggests that a VMC dysfunction would be found in patients with major depression. Previous reports are ambiguous on this matter. Therefore, the present study was undertaken in order to determine whether MD patients pass or fail a VMC test on which PD patients are known to be deficient.Sixty-five MD patients were tested. Fifty-four (83%) had normal VMC. VMC was found to be independent of age, disease duration, severity of depression, or treatment. A deficit was found in 12 patients (17%). In this group too, VMC capabilities did not correlate with depression, or its treatment.These results negate an effect of depression, its accompanying frontal cortical changes, or its treatment on VMC. We propose that abnormal VMC in depression indicates coexisting illness, including possible preclinical PD.