Pathogenesis of Kaposi's sarcoma.

Hematol Oncol Clin North Am

Pharmacology Program, Weill Graduate School of Medical Sciences of Cornell University, 1300 York Avenue, Room C406, New York, NY 10021, USA.

Published: June 2003

Kaposi's sarcoma (KS) is a disease characterized by proliferative vascular lesions, which almost invariably contain the KS-associated herpesvirus (KSHV), also called human herpesvirus 8. KSHV is a lymphotrophic and angiotrophic herpesvirus, whose genome encodes several proteins involved in proliferation, antiapoptotic functions, and inflammation. Most KS spindle cells express latent KSHV genes, but a few express lytic genes, which might be involved in angiogenic and paracrine mechanisms that contribute to KS pathogenesis. A number of tissue culture and mouse models have been established, but a comprehensive system that accurately portrays KS pathogenesis still does not exist.

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http://dx.doi.org/10.1016/s0889-8588(03)00044-3DOI Listing

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