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Mdm2 requires Sprouty4 to regulate focal adhesion formation and metastasis independent of p53.
Nat Commun
August 2024
Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.
Article Synopsis
- Researchers have discovered that Mdm2 and MdmX, known for regulating the p53 tumor suppressor, also play significant roles in cellular processes unrelated to p53, particularly in cell migration and invasion.
- In experiments with cells lacking p53, reducing Mdm2 or MdmX, as well as inhibiting their complex, negatively impacted cell movement, spreading, and attachment, and decreased metastasis in live models.
- The study highlights that Mdm2 represses the expression of Sprouty4, which is essential for its regulation of migration and adhesion, indicating a new mechanism influencing cancer cell behavior independent of p53.
PDK1-stabilized LncRNA SPRY4-IT1 promotes breast cancer progression via activating NF-κB signaling pathway.
Mol Carcinog
July 2023
Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Pyruvate dehydrogenase kinase 1 (PDK1) is a widely known glycolytic enzyme, and some evidence showed that PDK1 promoted breast cancer by multiple approaches. However, very few lncRNAs have been identified to be associated with PDK1 in breast cancer in previous research. In this study, we found that lncRNA sprouty4-intron transcript 1 (SPRY4-IT1) was regulated by PDK1 with correlation analysis, and PDK1 upregulated SPRY4-IT1 remarkably in breast cancer cells, as PDK1 interacted with SPRY4-IT1 in the nucleus and significantly enhanced the stability of SRPY4-IT1.
View Article and Find Full Text PDFSprouty4 is epigenetically upregulated in human colorectal cancer.
Epigenetics
December 2023
Department of Medicine, Division of Gastroenterology and Hepatology, University of Missouri, Columbia, Missouri, 65212, USA.
Sprouty4 (SPRY4) has been frequently reported as a tumor suppressor and is therefore downregulated in various cancers. For the first time, we report that SPRY4 is epigenetically upregulated in colorectal cancer (CRC). In this study, we explored DNA methylation and hydroxymethylation levels of in CRC cells and patient samples and correlated these findings with mRNA and protein expression levels.
View Article and Find Full Text PDFMacrophage Sprouty4 deficiency diminishes sepsis-induced acute lung injury in mice.
Redox Biol
December 2022
Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. Electronic address:
Objective: Inflammation and oxidative stress play critical roles in sepsis-induced acute lung injury (ALI). Sprout4 (Spry4) is involved in regulating inflammation and tissue injury; however, its role and mechanism in sepsis-induced ALI remain elusive.
Methods: Macrophage-specific Spry4 knockout (Spry4), transgenic (Spry4) mice and matched control littermates were generated and exposed to cecum ligation and puncture (CLP) surgery to establish bacterial sepsis-induced ALI.
Loss of Sprouty Produces a Ciliopathic Skeletal Phenotype in Mice Through Upregulation of Hedgehog Signaling.
J Bone Miner Res
November 2021
Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czech Republic.
Article Synopsis
- The Sprouty family plays a key role in modulating receptor tyrosine kinase (RTK) signaling pathways, and disruptions in their function are linked to structural issues in primary cilia, leading to ciliopathies.
- Transgenic mice lacking Sprouty2 and Sprouty4 show significant defects such as improper bone formation, digit patterning issues, and craniofacial abnormalities, which may be attributed to these ciliopathies.
- The study found that these mutant mice exhibit elongated cilia and increased Hedgehog signaling, suggesting that Sprouty protein deficiency can serve as a model to explore the connection between RTK overactivation and cilia dysfunction during bone development.
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