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FP-YOLOv8: Surface Defect Detection Algorithm for Brake Pipe Ends Based on Improved YOLOv8n.
Sensors (Basel)
December 2024
School of Mechanical and Power Engineering, Zhengzhou University, Zhengzhou 450000, China.
To address the limitations of existing deep learning-based algorithms in detecting surface defects on brake pipe ends, a novel lightweight detection algorithm, FP-YOLOv8, is proposed. This algorithm is developed based on the YOLOv8n framework with the aim of improving accuracy and model lightweight design. First, the C2f_GhostV2 module has been designed to replace the original C2f module.
View Article and Find Full Text PDFAdvances in Canine Anesthesia: Physiologically Based Pharmacokinetic Modeling for Predicting Propofol Plasma Profiles in Canines with Hepatic Impairment.
Pharmaceuticals (Basel)
December 2024
Department of Veterinary Medicine, Universidade Federal de Lavras, Lavras 37200-900, MG, Brazil.
: A PBPK model allows the prediction of the concentration of drug amounts in different tissues and organs over time and can be used to simulate and optimize different therapeutic protocols in healthy and sick individuals. The objective of this work was to create a PBPK model to predict propofol doses for healthy canines and canines with hepatic impairment. : The study methodology was divided into two major phases, in which the first phase consisted of creating the PBPK model for healthy canines, and in the second phase, this model was adjusted for canines with hepatic impairment.
View Article and Find Full Text PDFBehavior Change Techniques in Physical Activity Interventions Targeting Overweight and Obese Children and Adolescents: A Systematic Review.
Behav Sci (Basel)
November 2024
Physical Education College, Shanghai University, Shanghai 200444, China.
Substantial evidence globally confirms the benefits of physical activity (PA) interventions for the physical and mental health of overweight and obese children and adolescents. However, current research has yet to determine which behavior change techniques (BCTs) are most effective in PA interventions for this population. This systematic review aims to evaluate the application of BCTs in PA interventions for overweight and obese children and adolescents and to identify the most effective BCTs using the promise ratio.
View Article and Find Full Text PDFMultitarget Effects of Nrf2 Signalling in the Brain: Common and Specific Functions in Different Cell Types.
Antioxidants (Basel)
December 2024
Neurochemistry Research Institute, Department of Biochemistry and Molecular Biology, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a crucial regulator of cellular defence mechanisms, essential for maintaining the brain's health. Nrf2 supports mitochondrial function and protects against oxidative damage, which is vital for meeting the brain's substantial energy and antioxidant demands. Furthermore, Nrf2 modulates glial inflammatory responses, playing a pivotal role in preventing neuroinflammation.
View Article and Find Full Text PDFYu-Xue-Bi capsule ameliorates aggressive synovitis and joint damage in rheumatoid arthritis via modulating the SUCNR1/HIF-1α/TRPV1 axis.
Phytomedicine
December 2024
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Electronic address:
Background: Specific treatment for rheumatoid arthritis (RA) is still an unmet need. Yu-Xue-Bi (YXB) capsule effectively treats RA with blood stasis syndrome (BS). However, its mechanism remains unclear.
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