Primary Objective: To characterize a necrotic lesion using MRI and motor recovery using behavioural methods.
Research Design: Stroke model based on two steps: (1) development of a lesion using MR-imaging parameters and (2) behavioural recovery.
Methods And Procedures: Seventy male Sprague-Dawley rats were used. A focal lesion of the right sensorimotor cortex was induced photochemically.
Main Outcomes And Results: The maximum volume of oedema and the lesion damage was reached by approximately 6 hours. In the lesion area, the apparent diffusion coefficient (ADC) increased from 6 hours, then decreased from 24 hours. All animals spontaneously recovered motor function by day 10, despite the continued presence of the cortical lesion.
Conclusions: The results show that this model mimics a core lesion, as well as the late phase in a human stroke episode. This model might be used for longitudinal study of the basic mechanisms of motor recovery.
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