All D+ samples were detected by all monoclonal antibodies (mabs) without any problem. Very few of the 3,000 D- samples showed a +/- to ++ reaction with some of the IgG type mabs using the Coombs technique. It is still open whether these are specific reactions with weakly positive samples, which were negative with polyclonal sera. IgM type mabs detected up to 100% of the Du samples dependent on the Rh phenotype and the technique used (CCDuee > CcDuee > ccDuEe). Most of the CCDuee samples reacted very strongly and should no longer be regarded as Du.
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Results of the DGTI workshop on the evaluation of the reactivity of monoclonal anti-D.
Infusionsther Transfusionsmed
February 1992
Biotest AG, Research Dept, Dreieich, FRG.
All D+ samples were detected by all monoclonal antibodies without problems. Very few of the 3000 D- samples showed a +/- to ++ reaction with some of the IgG type mabs using the Coombs technique. It is still open whether these are specific reactions with weak positive samples, which were negative with polyclonal sera.
View Article and Find Full Text PDFResults of the DGTI workshop on the evaluation of the reactivity of monoclonal anti-D.
Beitr Infusionsther
July 1993
Biotest AG, Research Department, Dreieich, FRG.
All D+ samples were detected by all monoclonal antibodies (mabs) without any problem. Very few of the 3,000 D- samples showed a +/- to ++ reaction with some of the IgG type mabs using the Coombs technique. It is still open whether these are specific reactions with weakly positive samples, which were negative with polyclonal sera.
View Article and Find Full Text PDF[Preliminary results of the DGTI Workshop for evaluating the reactivity of monoclonal anti-D].
Beitr Infusionsther
May 1992
Biotest AG, Forschungszentrum, Offenbach.
Within a working group of the German transfusion society, a workshop was conducted to evaluate the reactivity of monoclonal anti-D supernatants. During this evaluation 10,000 samples were tested, including 325 Du-samples, with 3-5 IgM type antibodies and 3-4 IgG type antibodies, which were selected to also find 'D-variants'. In general, the reactivity with D+ red blood cells was good, and specific in respect to D negative samples.
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