Factors predictive of corticosteroid psychosis in patients with systemic lupus erythematosus.

Neurology

Department of Medicine, Tuen Mun Hospital, New Territories, Hong Kong SAR, China.

Published: July 2003

AI Article Synopsis

  • Corticosteroid-induced psychosis was found in 5% of 92 patients with systemic lupus erythematosus (SLE).
  • The occurrence of psychosis did not depend on how corticosteroids were administered or their dosage.
  • Key factors linked to psychosis included low serum albumin levels, history of anxiety disorders, and family history of psychiatric conditions, with hypoalbuminemia being the most significant after adjustment.

Article Abstract

Corticosteroid-induced psychosis occurred in 5% of a prospective cohort of 92 patients with systemic lupus erythematosus (SLE). Psychosis was unpredictable by the routes and dosage of corticosteroid used. Factors predictive of psychosis were low serum levels of albumin, complement, and creatinine; history of anxiety disorders; and a family history of psychiatric illnesses. After multivariate adjustment, only hypoalbuminemia remained significant.

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Source
http://dx.doi.org/10.1212/wnl.61.1.104DOI Listing

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