Insulintherapy is often the only way to obtain satisfactory glycaemic control in type 2 diabetic patients after several years of evolution of the disease. However, independently of the reluctance of the patient, it poses a few specific problems, and particularly that of weight gain initiating a vicious circle leading to deterioration of the metabolic control and to a progressive increase of insulin doses. Specific therapeutic protocols combining oral drugs and insulin have been promoted, but their efficacy is generally limited in course of time, and change to conventional or even intensified insulintherapy is in that case required. The practitioner will have to overcome his fear of using high insulin doses and give to therapeutic education the right place in order to guarantee the long term success of insulintherapy and so an effective prevention of diabetic complications.
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Open Vet J
November 2024
Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Background: Hyperglycemia is a condition in which blood sugar levels increase excessively due to a variety of factors, one of which is the body's inability to regulate insulin properly. Diabetes closely relates to this condition, which significantly contributes to premature death and disability. Long-term diabetes treatment accompanied by a strict diet provides real results in controlling blood glucose levels but can cause side effects.
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November 2024
Department of Pharmacology, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Diabetes mellitus represents a significant and growing global health challenge, with its prevalence steadily increasing. Insulin therapy remains a cornerstone of diabetes management. Since its discovery in 1921, insulin has undergone substantial advancements, evolving from crude animal extracts to highly refined recombinant formulations and biosimilars.
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Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
Background: Plant-based foods have reduced protein digestibility and frequently display unbalanced amino acid profiles. Plant-based foods are therefore considered inferior to animal-based foods in their anabolic potential. No study has assessed the anabolic potential of a vegan diet that provides a large variety of plant-based protein sources in older adults.
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Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan.
Lipid rafts are subdomains of the cell membrane that are rich in cholesterol and glycolipids, and they are involved in various cellular processes and pathophysiological mechanisms. However, the specific role of lipid rafts in hepatocyte dysfunction during the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) is not fully understood. In this study, we investigated the impact of lipid rafts on insulin sensitivity and hepatocyte injury induced by saturated free fatty acids (sFFAs) using primary-cultured mouse hepatocytes.
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Research and Development Station for Aquaculture and Aquatic Ecology, "Alexandru Ioan Cuza" University, Carol I, 20A, 700505 Iasi, Romania.
Although pesticides have been a constant concern for decades, in the last ten years, public discussions and scientific research have emphasized their impact on human health and the environment, drawing increased attention to the problems associated with their use. The association of environmental stressors such as pesticides with a sugar-rich diet can contribute to the growing global metabolic disease epidemic through overlapping mechanisms of insulin resistance, inflammation, and metabolic dysregulation. The main aim of this study was to evaluate the behavioral effects of the exposure of Silver crucian carp () to a commercial insecticide formulation containing fipronil, pyriproxyfen, and other additives, as well as sucrose and their mixtures.
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