Introduction: Essential thrombocythemia is a rare disease of unknown origin characterized by abnormal increase in the platelet count.
Case Report: We report a case diagnosed in a woman who had had an early miscarriage in her first pregnancy, a voluntary abortion because a fetal chromosomal aberration in the second pregnancy and at last a third normal pregnancy. Treatment with low-dose aspirin (100 mg/day) and the use of low molecular weight heparin in the last three weeks of gestation appears to improve the obstetric outcome.
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http://dx.doi.org/10.1007/s00404-003-0520-y | DOI Listing |
Cureus
December 2024
Academic Affairs and Research, Orlando Regional Medical Center, Orlando, USA.
Essential thrombocythemia (ET) is a type of myeloproliferative neoplasm (MPN) disorder characterized by persistent thrombocytosis and characterized by frequent association with cellular genetic alterations. The 10%-15% of ET that is not associated with genetic abnormalities is known as triple-negative essential thrombocythemia (TNET). A common complication observed in around 20% of ET patients is the development of acquired von Willebrand disease (AvWD).
View Article and Find Full Text PDFCureus
December 2024
Hematology and Oncology, Olive View University of California Los Angeles (UCLA) Medical Center, Sylmar, USA.
Primary myelofibrosis (PMF) is an uncommon chronic myeloproliferative disorder that is commonly associated with Janus kinase 2 (JAK-2), calreticulin (CALR), or thrombopoietin receptor (MPL) mutations. Pre-fibrotic PMF (also known as pre-PMF or early PMF) is a subtype of PMF that is defined by a lower grade of fibrosis. In this report, we present a rare case of warm autoimmune hemolytic anemia (wAIHA) associated with pre-PMF.
View Article and Find Full Text PDFZhongguo Shi Yan Xue Ye Xue Za Zhi
December 2024
Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Objective: To analyze the genes related to platelet activation in essential thrombocythemia (ET) based on transcriptome sequencing technology (RNA-seq), and to explore the potential targets related to ET thrombosis.
Methods: Blood samples from ET patients and healthy individuals were collected for RNA-seq, and differentially expressed lncRNAs, miRNAs, and mRNAs were selected to construct a lncRNA-miRNA-mRNA regulatory network. Differential mRNAs in the regulatory network were enriched and analyzed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG).
J Blood Med
December 2024
Department of Hematology, Hamad Medical Corporation, Doha, Qatar.
Bull Cancer
December 2024
Service de thérapie cellulaire et hématologie clinique, CHU de Clermont-Ferrand, 63100 Clermont-Ferrand, France; EA7453 CHELTER, université Clermont-Auvergne, Clermont-Ferrand, France.
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