AI Article Synopsis
- A series of compounds based on 5-spirocyclohexyl-3-(2,6-dimethylphenyl)-1,5-dihydro-2H-pyrrol-2-one were created and tested for their effectiveness against aphids, specifically Myzus persicae.
- Researchers experimented with different substituents on both the spirocyclohexyl ring and the dihydropyrrole ring to enhance insecticidal activity.
- Findings indicated that certain substituent groups, like methoxy and cyclopropylcarbonyloxy, significantly improved the insecticidal properties of the compounds.
Article Abstract
A series of 5-spirocyclohexyl-3-(2,6-dimethylphenyl)-1,5-dihydro-2H-pyrrol-2-one derivatives (3) with various substituents on the spirocyclohexyl ring was synthesized and evaluated for its insecticidal activity against the aphid, Myzus persicae. Substituents at the 1- and 4-positions of the dihydropyrrole ring were also varied to optimize the activity. An investigation of the structure-activity relationship revealed that methoxy, alkoxyalkoxy, ethylenedioxy and methoxyimino groups were favorable as substituents at the 4-position of the spirocyclohexyl ring. The activity was optimized by the respective substitution of a methoxy or methoxymethoxy moiety and cyclopropylcarbonyloxy group at the 1- and 4-positions of the dihydropyrrole ring.
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| http://dx.doi.org/10.1271/bbb.67.1230 | DOI Listing |
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