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Inflammation scores based on C-reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis.
Immun Ageing
October 2024
Department of Clinical and Molecular Sciences, Università Politecnica Delle Marche, Ancona, Italy.
Article Synopsis
- Systemic inflammation raises the risk of mortality in hospitalized older patients, especially in the context of age-related diseases and infections like COVID-19.
- Inflammatory biomarkers such as the C-reactive protein to albumin ratio (CAR) and various prognostic scores (GPS, mGPS, hs-mGPS) effectively predict short-term mortality but are often underused for this purpose.
- The study involving 3,206 geriatric patients found that higher CAR and higher GPS scores significantly correlated with increased mortality risk, especially in men, indicating that these inflammatory markers can help assess in-hospital mortality risk in older adults.
Determining the residual volume in peritoneal dialysis using low molecular weight markers.
Perit Dial Int
August 2024
Department of Clinical Sciences Lund, Skane University Hospital, Lund University, Lund, Sweden.
Background: Variation in residual volume between peritoneal dialysis dwells creates uncertainty in ultrafiltration determination, dialysis efficiency, and poses a risk of overfill if the residual volume is large. Measuring the dilution of a marker molecule during fluid fill offers a convenient approach, however, estimation accuracy depends on the choice of dilution marker. We here evaluate the feasibility of creatinine and urea as dilution markers compared to albumin-based residual volumes and three-pore model estimations.
View Article and Find Full Text PDFPreparation of stable and monodisperse paclitaxel-loaded bovine serum albumin nanoparticles via intermolecular disulfide crosslinking.
Biochem Biophys Rep
July 2024
Laboratory of Pharmaceutics, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe, 658-8558, Japan.
Paclitaxel (PTX) is one of the most used anti-cancer drugs worldwide. Due to its insolubility in water, the clinically available liquid formulation of PTX contains Cremophor EL that is responsible for severe hypersensitivity. Albumin-based nanoparticles have emerged as a promising carrier for anti-cancer drugs because albumin nanoparticles have high capacity to not only load lipophilic drugs without solubilizer but also accumulate in tumor by both passive and active mechanisms.
View Article and Find Full Text PDFSystemic inflammation May limit the effect of protein supplement on nutritional status in peritoneal dialysis.
Clin Nutr ESPEN
June 2022
Unidad de Investigación Biomédica 02, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano Del Seguro Social, Guadalajara, Mexico.
Background: Malnutrition and inflammation are highly prevalent and associated with poor outcomes in continuous ambulatory peritoneal dialysis (CAPD). Nutritional supplements are commonly used; however, presence of systemic inflammation could limit their effect.
Aim: To evaluate the impact of systemic inflammation on nutritional status of CAPD patients receiving an oral protein supplement.
Superior Dialytic Removal of Bilirubin and Bile Acids by Free Fatty Acid Displacement and Its Synergy With Albumin-Based Dialysis.
ASAIO J
January 2023
Department of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
One of the cardinal features of any liver replacement therapy is the ability to remove accumulated metabolites. However, an unsolved problem is the low dialyzability of lipophilic toxins. This study aimed to explore whether bilirubin and bile acids removal can be increased by free fatty acid (FFA) displacement and its synergy with albumin dialysis.
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