Commercially available molybdenum hexacarbonyl serves as a convenient and solid carbon monoxide source in palladium-catalyzed aminocarbonylations of aryl bromides and iodides. This improved microwave protocol, relying on DBU as base and THF as solvent, enables rapid couplings using otherwise sluggish anilines, tert-butylamine, and free amino acids. In addition, Cr(CO)(6) and W(CO)(6) were found to be useful alternative CO-releasing reagents. Altogether, 16 different aromatic amides were synthesized under air in 35-95% yield after only 15 min of controlled microwave irradiation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jo034382d | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhancing farmer awareness: Vertical transmission of Neospora caninum in aborting cattle and the value of diagnostics tools.
Vet Parasitol
January 2025
Institute of Parasitology, Vetsuisse Faculty, University of Bern, Länggassstrasse 122, Bern 3012, Switzerland. Electronic address:
The protozoan parasite Neospora caninum is an important cause of abortion in cattle. Infection occurs horizontally by ingestion of oocysts shed by canids or vertically, from an infected dam to the foetus, and may result in abortion, stillbirth, or the birth of subclinically infected offspring. We estimated the occurrence of N.
View Article and Find Full Text PDFAnalyzing the channels of information dissemination: Investigating abrupt transitions in resource investment.
Chaos
January 2025
Department of Applied Mathematics, College of Applied Sciences, Kyung Hee University, Yongin 17104, Republic of Korea.
Investment in resources is essential for facilitating information dissemination in real-world contexts, and comprehending the influence of resource allocation on information dissemination is, thus, crucial for the efficacy of collaborative networks. Nonetheless, current studies on information dissemination frequently fail to clarify the complex interplay between information distribution and resources in network contexts. In this work, we establish a resource-based information dissemination model to identify the complex interplay by examining the propagation threshold and equilibriums.
View Article and Find Full Text PDFPolylactic Acid Micro/Nanoplastic Exposure Induces Male Reproductive Toxicity by Disrupting Spermatogenesis and Mitochondrial Dysfunction in Mice.
ACS Nano
January 2025
Department of Urology, Peking University First Hospital, Beijing 100034, China.
Although considered an "eco-friendly" biodegradable plastic, polylactic acid (PLA) microplastic (PLA-MP) poses a growing concern for human health, yet its effects on male reproductive function remain underexplored. This study investigated the reproductive toxicity of PLA in male mice and its potential mechanisms. To this end, our in vivo and in vitro experiments demonstrated that after degradation in the digestive system, a significant number of PLA-MP-derived nanoparticles could penetrate the blood-testis barrier (BTB) and localize within the spermatogenic microenvironment.
View Article and Find Full Text PDFEnhancing Diagnostic Accuracy of Lung Nodules in Chest Computed Tomography Using Artificial Intelligence: Retrospective Analysis.
J Med Internet Res
January 2025
Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Background: Uncertainty in the diagnosis of lung nodules is a challenge for both patients and physicians. Artificial intelligence (AI) systems are increasingly being integrated into medical imaging to assist diagnostic procedures. However, the accuracy of AI systems in identifying and measuring lung nodules on chest computed tomography (CT) scans remains unclear, which requires further evaluation.
View Article and Find Full Text PDFDespite advancements in surgical techniques for rotator cuff repair, retear rates remain a significant concern. This study systematically reviews the evidence on the effectiveness of the Regeneten Bioinductive Implant in improving healing outcomes. A systematic review of the literature was conducted by searching on PubMed, Embase, Web of Science Core Collection and Cochrane Library.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!