An expedient and scalable synthesis of a versatile new analytical construct intermediate 1 is described. The utility of the intermediate 1 is exemplified by the preparation of the construct resin 14 incorporating an acid-labile linker which is used to conveniently develop optimized conditions leading to the preparation of a small compound array 24(1-3,1-3). The optimized conditions are shown to work equally well on both the construct resin 14 and the corresponding base resin 15.
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http://dx.doi.org/10.1021/jo034340p | DOI Listing |
Advancements in DNA sequencing technology have facilitated the generation of a vast number of DNA sequences, posing opportunities and challenges for constructing large phylogenetic trees. DNA barcode sequences, particularly COI, represent extensive orthologous sequences suitable for phylogenetic analysis. Phylogenetic placement analysis offers a promising method to integrate COI data into tree-building efforts, yet the impacts of backbone tree completeness and species composition remain under-explored.
View Article and Find Full Text PDFR Soc Open Sci
January 2025
Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK.
The influence of landscape structure on epidemic invasion of agricultural crops is often underestimated in the construction and analysis of epidemiological models. Computer simulations of individual-based models (IBMs) are widely used to characterize disease spread under different management scenarios but can be slow in exploring large numbers of different landscape configurations. Here, we address the problem of finding an analytical measure of the impact of the spatial structure of a crop landscape on the invasion and spread of plant pathogens.
View Article and Find Full Text PDFJTCVS Open
December 2024
Division of Cardiothoracic Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC.
Objective: Machine learning (ML) may allow for improved discernment of hemodynamics and oxygen delivery compared to standard invasive monitoring. We hypothesized that an ML algorithm could predict impaired delivery of oxygen (IDO) with comparable discrimination to invasive mixed venous oxygen saturation (SvO) measurement.
Methods: A total of 230 patients not on mechanical circulatory support (MCS) managed with a pulmonary artery catheter (PAC) were identified from 1012 patients admitted to a single cardiovascular intensive care unit (CVICU) between April 2021 and January 2022.
Sci Rep
January 2025
Key Laboratory for Information System of Mountainous Area and Protection of Ecological Environment of Guizhou Province, Guizhou Normal University, Guian, 550025, China.
Removal of accumulated dyes from the environment water bodies is essential to prevent further harm to humans. The development and design of new alternative nanoadsorbents that can conveniently, quickly, and efficiently improve the adsorption and removal efficiency of dyes from wastewater remains a huge challenge. An amorphous TiO with a magnetic core-shell-shell structure (FeO@PDA@a-TiO, denoted as FPaT) was constructed through a series of steps.
View Article and Find Full Text PDFWaste Manag
January 2025
College of Civil Engineering, Nanjing Forestry University, Nanjing, 210037, China.
The utilization of natural waste gravel soil as base course material contributes to environmental protection and carbon emission reduction. The purpose of this research is to establish a new model for automated gradation design of the composite soil stabilizer-stabilized waste gravel soil (CSSWGS). A gradation range of CSSWGS has been proposed.
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