AI Article Synopsis

  • Two cases of persistent urogenital sinus (UGS) with bladder and vaginal duplication were reported in infants experiencing recurrent urinary tract infections.
  • Diagnosis involved cystoscopy and vaginoscopy to assess the condition before surgical intervention.
  • A surgical repair utilized a midline abdominal and perineal approach, revealing complex anatomy that required a tailored surgical strategy.

Article Abstract

We report 2 cases of persistent urogenital sinus (UGS) with duplication of the bladder and vagina in different planes. Cystoscopy and vaginoscopy were used to diagnose persistent UGS with bladder and vaginal duplication in 2 infants with recurrent urinary tract infection. Surgical repair was done by way of a midline abdominal and perineal approach using tubularized UGS to reconstruct the urethra. Persistent UGS represents a major anomaly; these patients had the added complexity of duplication of the bladder and vagina. In these complex patients, the true anatomy may only become apparent during the surgical reconstruction, necessitating a flexible, individual approach.

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0090-4295(02)02545-1DOI Listing

Publication Analysis

Top Keywords

urogenital sinus
8
duplication bladder
8
bladder vagina
8
persistent ugs
8
bladders vaginas
4
vaginas planes
4
planes urogenital
4
sinus report
4
report cases
4
cases persistent
4

Similar Publications

The most common form of congenital adrenal hyperplasia (CAH) is secondary to 21-hydroxylase deficiency (21OHD). This review will summarize the clinical manifestations, recommended treatments, monitoring, clinical challenges and management strategy, and treatment challenges in special situations for infants and children with classic CAH due to 21OHD. Specifically, we review newborn screening and the initial diagnosis, glucocorticoid and mineralocorticoid treatment, and recommended monitoring, including anthropometric and laboratory measures.

View Article and Find Full Text PDF
Article Synopsis
  • The lower urinary tract, consisting of the bladder and urethra, develops from the cloaca, with the bladder forming from the urogenital sinus and the urethra extending into the genital tubercle.
  • Engineering a fully functional bladder lining is challenging, and the urethral epithelium's immune roles are under-researched, highlighting the need for a better understanding of the epithelial and mesenchymal interactions that drive development.
  • This study identified specific genes involved in bladder and urethra development in mice, revealing differences in gene expression patterns related to sex and offering insights for future regenerative therapies.
View Article and Find Full Text PDF

Repair of Microperforate Hymen.

J Pediatr Adolesc Gynecol

January 2025

Division of Pediatric and Adolescent Gynecology, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine.

Objective: Subocclusive variants of the hymen are a group of hymenal anomalies that result due to a failure of canalization of the urogenital sinus. One of these variations is the microperforate hymen, for which accurate incidence is unknown. Microperforate hymen is a non-obstructing variation that allows for menstrual egress and often patients present due to inability to use a tampon.

View Article and Find Full Text PDF

46,XY sex reversal 11 (SRXY11) is a rare and recently identified form of 46,XY difference in sexual development (DSD), caused by variants in the DEAH-Box Helicase 37 gene (). is crucial for ribosome biogenesis, but its specific role in gonadal development remains unclear. The genital phenotype varies widely, ranging from typical female to typical male.

View Article and Find Full Text PDF

Signs of virilization, such as clitoromegaly, labio-scrotal fusion, and urogenital sinus may be observed in females with 21-hydroxylase deficiency (21-OHD) and other rare virilizing forms of congenital adrenal hyperplasia (CAH). This makes sex determination difficult, and multiple reconstructive surgeries in the postnatal period may be required. As 21-OHD is an autosomal recessive disease, the chance of any child being affected is one in four and so only one in eight will be an affected female.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!