Objective: To study the role of interleukin-1beta (IL-1beta) in the pathogenesis of acute respiratory distress syndrome (ARDS).
Methods: The bronchoalveolar lavage fluid (BALF) and serum in 13 patients with ARDS and 9 healthy controls were collected. The contents of IL-1beta were measured by enzyme-linked immunoadsorbent assay(ELISA).
Results: The levels of IL-1beta in BALF [(144.67+/-80.79)ng/L] and serum [(45.71+/-7.09)ng/L] in patients with ARDS were significantly higher than those in the control groups [(20.39+/-1.87)ng/L, P=0.000; (35.06+/-5.46)ng/L, P=0.001, respectively], and the levels of IL-1beta in BALF were also significantly higher than those of the serum in the patients with ARDS (P=0.000).
Conclusion: The results indicate that IL-1beta is involved in the pathogenesis of ARDS. Early determination of IL-1beta level in BALF may be more valuable in the evaluation of disease process of ARDS.
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