AI Article Synopsis
- Sjögren's syndrome (SS) is an autoimmune disease that primarily affects salivary and tear glands, leading to dryness in the mouth and eyes.
- Nearly one-third of SS patients experience systemic symptoms beyond gland dysfunction.
- Advances in understanding the disease's mechanisms, including the involvement of retroviruses, cytokines, and aquaporins, offer new treatment options for both local and systemic effects.
Article Abstract
Sjögren's syndrome (SS) is a common autoimmune disease characterized by destruction and dysfunction of the salivary and lachrymal glands. Systemic manifestations occur in almost one third of patients with SS. Treatment of SS has been long considered as disappointing, being mainly restricted to local management with artificial tears and oral lubricants or to the use of immunosuppression-based therapies for systemic disease. Better knowledge of the pathogenesis of SS, including the role of retroviruses and cytokines and the discovery of aquaporins, provides new perspectives for the local and systemic management of this disease. Our goal is to focus on these recent therapeutic progresses.
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