Results of surgical treatment of 318 patients with an acute appendicitis, using principles of antibioticoprophylaxis and antibacterial therapy, new medicinal preparations, were analyzed.
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Study on the Electrical and Mechanical Properties of TiC Particle-Reinforced Copper Matrix Composites Regulated by Different Rare Earth Elements.
Nanomaterials (Basel)
January 2025
State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China.
Copper matrix composites (CMCs) synergistically reinforced with rare earth oxides (ReO) and TiC were prepared using a powder metallurgy process with vacuum hot-pressing and sintering technology, aiming to explore new ways to optimize the properties of composites. Through this innovative approach, we propose a new solution strategy and idea for the difficult problem of mutual constraints between electrical and mechanical properties faced by traditional dual-phase reinforced Cu-matrix composites. Meanwhile, the modulation mechanism of ReO in CMCs and the electrical and mechanical properties of the composites were investigated.
View Article and Find Full Text PDFMapping the Transition of Adolescents to Adult HIV Care: A Mixed-Methods Perspective from the Cape Town Metropole, South Africa.
Trop Med Infect Dis
December 2024
School of Nursing, University of the Western Cape, Cape Town 7535, South Africa.
(1) Background: Globally, an estimated 1.7 million adolescents (aged 10-19 years) were living with HIV in 2023, with 82% residing in sub-Saharan Africa. For ALHIV, transitioning to adult care involves assuming responsibility for their own health and disease management, posing significant challenges to persistent engagement in care.
View Article and Find Full Text PDFDoes Caregiver Engagement Predict Outcomes of Adolescent Wilderness Therapy?
Behav Sci (Basel)
January 2025
Pine River Institute, 180 Dundas Street West, Suite 1410, Toronto, ON M5G 1Z8, Canada.
Existing research shows some links between wilderness therapy outcomes and familial functioning. However, wilderness therapy programs do not agree on what kind of caregiver involvement is required to improve adolescent program outcomes, nor has research examined different types of family engagement and their impact on adolescent treatment outcomes. Thus, the present study explored the research question: Does caregiver engagement in adolescent wilderness therapy foster improved outcomes? The study sample consisted of 4067 adolescent wilderness therapy clients from 12 different wilderness therapy programs.
View Article and Find Full Text PDFBackground: Antibody-drug conjugate (ADC) is an anticancer drug that links toxins to specifically targeted antibodies via linkers, offering the advantages of high target specificity and high cytotoxicity. However, complexity of its structural composition poses a greater difficulty for drug design studies.
Objectives: Pharmacokinetic/pharmacodynamic (PK/PD) based consideration of ADCs has increasingly become a hot research topic for optimal drug design in recent years, providing possible ideas for obtaining ADCs with desirable properties.
A global review of national guidelines of post-exposure prophylaxis for the prevention of HIV.
J Int AIDS Soc
January 2025
Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia.
Introduction: The World Health Organization (WHO) recommends the use of antiretroviral drugs as post-exposure prophylaxis (PEP) for preventing HIV acquisition for occupational and non-occupational exposures. To inform the development of global WHO recommendations on PEP, we reviewed national guidelines of PEP for their recommendations.
Methods: Policies addressing PEP from 38 WHO HIV priority countries were obtained by searching governmental and non-governmental websites and consulting country and regional experts; these countries were selected based on HIV burden, new HIV acquisitions and the number of HIV-associated deaths.
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