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Alterations in LDL and HDL after an ischemic stroke associated with carotid atherosclerosis are reversed after 1 year.
J Lipid Res
December 2024
Cardiovascular Biochemistry Group, Institut de Recerca Sant Pau, (IR Sant Pau), Barcelona, Spain; CIBER of Diabetes and Metabolic Diseases (CIBERDEM), Spain. Electronic address:
Approximately 20% of ischemic strokes are attributed to the presence of atherosclerosis. Lipoproteins play a crucial role in the development of atherosclerosis, with LDL promoting atherogenesis and HDL inhibiting it. Therefore, both their concentrations and their biological properties are decisive factors in atherosclerotic processes.
View Article and Find Full Text PDFAtherogenic circulating lipoproteins in ischemic stroke.
Front Cardiovasc Med
December 2024
Cardiovascular Biochemistry Group, Institut de Recerca Hospital de Sant Pau (IR Sant Pau), Barcelona, Spain.
The fundamental role of qualitative alterations of lipoproteins in the early development of atherosclerosis has been widely demonstrated. Modified low-density lipoproteins (LDL), such as oxidized LDL (oxLDL), small dense LDL (sdLDL), and electronegative LDL [LDL(-)], are capable of triggering the atherogenic process, favoring the subendothelial accumulation of cholesterol and promoting inflammatory, proliferative, and apoptotic processes characteristic of atherosclerotic lesions. In contrast, high-density lipoprotein (HDL) prevents and/or reverses these atherogenic effects.
View Article and Find Full Text PDFComputational analysis of the alpha-2 domain of apolipoprotein B - 100, a potential triggering factor in LDL aggregation.
Biochim Biophys Acta Gen Subj
February 2025
Department of Chemistry, York College of the City University of New York, Jamaica, New York 11451, USA; PhD Programs in Chemistry and Biochemistry, Graduate Center of the City University of New York, New York 10016, USA. Electronic address:
Atherosclerosis, the major underlying cause of cardiovascular disease, is believed to arise from the accumulation of low-density lipoprotein (LDL) in the arterial subendothelial space, ultimately leading to plaque formation. It is proposed that the accumulation of LDL is linked to its intrinsic aggregation propensity. Although the native LDL is not prone to aggregation, LDL(-), an electronegative LDL characterized in the plasma, has been shown to prime LDL aggregation in a domino-like behavior similar to amyloidogenic proteins.
View Article and Find Full Text PDFAtherogenic low-density lipoprotein and cardiovascular risk.
Curr Opin Lipidol
February 2025
Consorcio CIBER, Pathophysiology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, Madrid.
Purpose Of Review: Despite reductions in low-density lipoprotein (LDL) cholesterol (LDLc), residual cardiovascular risk remains due to factors beyond lipoprotein levels, such as LDL particle count, size, electronegativity and modifications. Technological advances allow detailed profiling of LDL particles, offering potential biomarkers for diagnosis, prognosis, and treatment of cardiovascular disease (CVD). The aim of this review is to provide an updated overview of the state of knowledge in the field of LDL atherosclerotic role, which is evolving rapidly due to technological advances in biomarker measurement and applications.
View Article and Find Full Text PDFPotential Cognitive Decline Linked to Electronegative L5 in Type 2 Diabetes: A Holo-Hilbert Spectral Analysis.
Neuroendocrinology
November 2024
Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Article Synopsis
- Patients with type 2 diabetes mellitus (T2DM) show a higher risk of cognitive impairment, prompting a study on the effects of a specific LDL-C subfraction called L5 on their cognitive function.
- The study involved 68 T2DM patients, examining their cognitive abilities and using a new analysis method, HHSA, to assess the impact of L5 on neural activity.
- Results indicated that higher L5 levels are linked to increased risks of mild cognitive impairment (MCI) and Alzheimer’s disease, with a negative correlation between L5 and cognitive performance, particularly in MCI patients, suggesting L5 could serve as a useful biomarker for cognitive decline in T2DM.
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