AI Article Synopsis
- The study investigated how the hypothalamus affects body temperature in male rats by disrupting the midbrain's tonic inhibitory mechanism (TIM) on heat production from brown adipose tissue (BAT).
- Removing the TIM using procaine injections led to increased rectal temperatures and skin temperature changes in unanesthetized rats, but decerebrated rats showed fatal hyperthermia without the skin temperature rise.
- Findings indicate that the midbrain's TIM can function independently in conscious rats and suggests the hypothalamus plays a role in regulating BAT heat production when the TIM is disrupted.
Article Abstract
Influence of the hypothalamus on increased body temperature was examined in male rats. Body temperature was increased by removing the midbrain tonic inhibitory mechanism (TIM) on heat production from brown adipose tissue (BAT) by microinjections of a local anesthetic, procaine, into the midbrain. Procaine microinjections in unanesthetized rats increased rectal temperature that was followed by a strong tail skin temperature rise. Procaine microinjections in unanesthetized and decerebrated rats also increased rectal temperature but without skin temperature rise. These decerebrated animals fatally developed hyperthermia. In anesthetized rats, procaine microinjections increased temperature of the interscapular BAT (IBAT) higher with shorter onset for temperature rise than rectal temperature. Increased IBAT temperature by procaine microinjections in anesthetized rats was attenuated during hypothalamic warming, and enhanced during hypothalamic cooling when compared with that observed during thermoneutral hypothalamic temperature. These results suggest that the midbrain TIM is able to function in unanesthetized conscious rats, and that the integrity of the midbrain mechanism to tonically inhibit metabolic heat production does not require the presence of intact hypothalamus. These results also suggest that the hypothalamus modulates directly or indirectly IBAT heat production that was induced by removal of the midbrain TIM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0361-9230(03)00080-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Time-resolved effects of short-term overfeeding on energy balance in mice.
Diabetes
January 2025
Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
To curb the obesity epidemic, it is imperative that we improve our understanding of the mechanisms controlling fat mass and body weight regulation. While great progress has been made in mapping the biological feedback forces opposing weight loss, the mechanisms countering weight gain remain less well defined. Here, we integrate a mouse model of intragastric overfeeding with a comprehensive evaluation of the regulatory aspects of energy balance, encompassing food intake, energy expenditure, and fecal energy excretion.
View Article and Find Full Text PDFInnovative method integrates play fairway analysis supported with GIS and seismic modeling for geothermal potential evaluation in a basement reservoir.
Sci Rep
January 2025
Faculty of Earth and Environmental Sciences and Engineering, Institute of Exploration Geosciences, University of Miskolc, Miskolc, Hungary.
The growing demand for clean and sustainable energy sources has prompted the investigation of numerous renewable and ecologically friendly options. Among these, geothermal energy is particularly noteworthy because of its widespread availability, compact size, and consistent, weather-independent power production. A geothermal play fairway analysis (GPFA) model was created for the study area, which is located in Békés county, southeastern Hungary.
View Article and Find Full Text PDFUnlocking dual-mode enzyme activities on bacterial surface: Directional recognition and swift capture of Alicyclobacillus acidoterrestris from fruit juices.
Food Res Int
January 2025
State Key Laboratory of Marine Food Processing and Safety Control, Dalian Polytechnic University, Dalian 116034, Liaoning, China. Electronic address:
The acidophilic and heat-resistant characteristics of Alicyclobacillus acidoterrestris (A. acidoterrestris) pose significant challenges to fruit juice production. Traditional thermal removal methods are often ineffective against this resilient bacterium.
View Article and Find Full Text PDFInsights into the regulation mechanisms of dual hydrothermal treatment on the structure and digestive characteristics of A- and B-type wheat starch granules.
Food Res Int
January 2025
State Key Laboratory of Crop Stress Adaptation and Improvement, College of Agriculture, Henan University, Kaifeng 475004, China; Food Laboratory of Zhongyuan, Luohe 462300, China. Electronic address:
Hydrothermal treatment is a physical modification technology to alter starch structures for the production of resistant starch (RS). However, the underlying regulation mechanism of the multiscale structure and digestive properties of starch by dual hydrothermal synergistic treatment remains unclear. To solve this problem, A- and B-type wheat starch granules (AWS and BWS) were separated and subjected to toughening and heat-moisture synergistic treatment (THT) with various moisture content (10 %, 15 %, 20 %, 25 %).
View Article and Find Full Text PDFHolocellulose nanofibrils biomimetic entrapment of liquid metal enable ultrastrong, tough, and lower-voltage-driven paper device.
Carbohydr Polym
March 2025
Beijing Key Laboratory of Lignocellulosic Chemistry, MOE Engineering Research Center of Forestry Biomass Materials and Energy, Beijing Forestry University, Beijing 100083, China; State Key Laboratory of Efficient Production of Forest Resources, Beijing 100083, China. Electronic address:
Integrating liquid metal (LM) with wood fibers for flexible paper electronics is intriguing yet extremely challenging due to poor mechanical performance. Here, we disclose a hemicellulose trapping strategy to achieve exceptional ultrastrong and tough LM-based paper electronics. Holocellulose nanofibrils (HCNFs) with hemicellulose retention of approximately 20 % are found to effectively entrap nanoscale LM within the fibril network, analogous to spider silk capturing small water droplets.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!