Objective: To investigate the effect of "Qiang Gu Kang Wei" prescription on bone metabolism in simulated weightless rats.
Method: Male SD rats were randomly divided into five groups: 1) free active control (FAC); 2) tail-suspended control (TS); 3) tail-suspended and treated with large dose of the prescription (TS + L) (30 g/kg); 4) tail-suspended and treated with middle dose of the prescription (TS + M) (20 g/kg); 5) tail suspended and treated with small dose of the prescription (TS + S) (10 g/kg). The experiment lasted 3 weeks. The effect of the prescription on bone biomechanical properties, bone density, bone mineral contents, and bone biochemical markers of bone metabolism were examined.
Result: Bone biomechanical properties, bone density, total and bound bone gla protein (BGP) of serum all increased significantly in three groups treated with the prescription.
Conclusion: "Qiang Gu Kang Wei" prescription prevents bone loss, hence maintains bone density and bone biomechanical properties under simulated weightlessness.
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