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- Research conducted on 3,400 febrile patients in Peru between 2020-2021 revealed a positive case of Rio Mamore hantavirus, highlighting the endemic presence of this virus in the region.
- Genetic analysis showed a strong similarity to past rodent-associated hantavirus cases from Loreto, indicating ongoing circulation.
- Findings suggest the need for enhanced hantavirus diagnostics and surveillance in Peru and Latin America due to the detection of multiple distinct hantavirus strains.
Phase 1 clinical trial of Hantaan and Puumala virus DNA vaccines delivered by needle-free injection.
NPJ Vaccines
November 2024
Clinical Trials Center, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.
Hantaan virus (HTNV) and Puumala virus (PUUV) are pathogenic zoonoses found in Asia and Europe, respectively. We conducted a randomized Phase 1 clinical trial of individual HTNV and PUUV DNA vaccines targeting the envelope glycoproteins (GnGc), as well as a combined HTNV/PUUV DNA vaccine delivered at varying doses using the PharmaJet Stratis® needle-free injection system (NCT02776761). Cohort 1 and 2 vaccines consisted of 2 mg/vaccination of HTNV or PUUV plasmid, respectively.
View Article and Find Full Text PDFAnalysis of Clinical and Laboratory Profiles of Patients Hospitalized with Hemorrhagic Fever with Renal Syndrome in Southwestern South Korea.
Am J Trop Med Hyg
January 2025
Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea.
Hemorrhagic fever with renal syndrome (HFRS) is caused by hantaviruses. Data of 34 patients with HFRS hospitalized at Chosun University Hospital, South Korea, between 2010 and 2021 were retrospectively analyzed. Nested reverse transcription polymerase chain reaction (RT-nPCR) targeting the L segment of hantavirus and sequencing were used for diagnosis.
View Article and Find Full Text PDFA comprehensive investigation of Glycoprotein-based nucleic acid vaccines for Hantaan Virus.
NPJ Vaccines
October 2024
Department of Immunology, Basic Medicine School, Air-Force Medical University (The Fourth Military Medical University), Xi'an, China.
Article Synopsis
- Hemorrhagic fever with renal syndrome (HFRS) is a serious illness in Eurasia with no specific treatments currently available, highlighting the need for safe and effective vaccines.
- Researchers developed three types of nucleic acid vaccine candidates (mRNA, naked DNA, and DNA in lipid nanoparticles) targeting the Hantaan virus to assess their potential against HFRS.
- All vaccine candidates successfully triggered strong immune responses similar to an existing inactivated vaccine, with the mRNA vaccine showing a robust T-helper 1 cell response and the DNA-LNP producing higher neutralizing antibodies, suggesting that combining these vaccines could enhance their effectiveness.
Identification and validation of cross-reactivity of anti-Thailand orthohantavirus nucleocapsid peptides.
Hum Immunol
November 2024
Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala 147004, India. Electronic address:
A Thailand orthohantavirus (THAIV) is endemic in Southeast Asia. This assumption is supported by isolation of THAIV from local small mammals. Also, anti-orthohantavirus antibodies were detected in human serum.
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