Optokinetic nystagmus in panoramic mono- and binocular optokinetic stimulation was studied in 24 patients with multiple sclerosis and 20 normal subjects. In control group, asymmetry coefficients and slow phase speed were less than 6% and 7.7% respectively. In the patients, these indices were 7.1 and 14% for binocular optokinetic stimulation and 14.6 and 21.7% for monocular one. Using monocular optokinetic stimulation, electronistagmographic signs of internuclear ophthalmoplegia were detected in all the patients. Therefore, panoramic monocular optokinetic stimulation facilitates determination of joint eye movement disturbances on subclinical level.
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