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A comprehensive review on early detection of drusen patterns in age-related macular degeneration using deep learning models.
Photodiagnosis Photodyn Ther
December 2024
School of Computer Science and Engineering, Vellore Institute of Technology, Chennai, India. Electronic address:
Age-related Macular Degeneration (AMD) is a leading cause of visual impairment and blindness that affects the eye from the age of fifty-five and older. It impacts on the retina, the light-sensitive layer of the eye. In early AMD, yellowish deposits called drusen, form under the retina, which could result in distortion and gradual blurring of vision.
View Article and Find Full Text PDFLongitudinal Assessment of Age-Related Macular Degeneration Using Ultrawidefield Imaging: The Optos Peripheral Retina Follow-up Study.
Ophthalmology
November 2024
Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin. Electronic address:
Purpose: With the widespread availability of Ultrawidefield (UWF) imaging, peripheral retinal abnormalities in age-related macular degeneration (AMD) have garnered attention. However, longitudinal studies of AMD peripheral findings are limited. This study aimed to characterize and quantify these features over 5 years.
View Article and Find Full Text PDFExtensive macular atrophy with pseudodrusen-like appearance (EMAP) clinical characteristics, diagnostic criteria, and insights from allied inherited retinal diseases and age-related macular degeneration.
Prog Retin Eye Res
January 2025
Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France; CHNO des Quinze-Vingts, Centre de Référence Maladies Rares REFERET and DHU Sight Restore, INSERM-DGOS CIC1423, Paris, France. Electronic address:
Extensive macular atrophy with pseudodrusen-like appearance (EMAP) was first described in France in 2009 as a symmetric and rapidly progressive form of macular atrophy primarily affecting middle-aged individuals. Despite the recent identification of a significant number of cases in Italy and worldwide, EMAP remains an underrecognized condition. The clinical triad typical of EMAP consists of vertically oriented macular atrophy with multilobular borders, pseudodrusen-like deposits across the posterior pole and mid-periphery, and peripheral pavingstone degeneration.
View Article and Find Full Text PDFMorphology and incidence of drusen-like deposits in peripheral retina of eyes with high myopia.
Eye (Lond)
November 2024
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
Article Synopsis
- The study aimed to analyze the presence and characteristics of peripheral drusen-like deposits (DLDs) in patients with pathological myopia using advanced imaging techniques.
- A total of 676 patients (1352 eyes) were reviewed, revealing that 4.9% of eyes had DLDs, primarily in older patients, with some cases linked to myopic macular neovascularization.
- The research indicates that these findings could inform the understanding of how peripheral retinal changes evolve in cases of pathological myopia.
Retinal G-protein-coupled receptor deletion exacerbates AMD-like changes via the PINK1-parkin pathway under oxidative stress.
FASEB J
October 2024
Department of Ophthalmology, Peking University People's Hospital, Beijing, China.
The intake of high dietary fat has been correlated with the progression of age-related macular degeneration (AMD), affecting the function of the retinal pigment epithelium through oxidative stress. A high-fat diet (HFD) can lead to lipid metabolism disorders, excessive production of circulating free fatty acids, and systemic inflammation by aggravating the degree of oxidative stress. Deletion of the retinal G-protein-coupled receptor (RGR-d) has been identified in drusen.
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