O-glucuronides and O-glucosides of a series of pyrazoles analogues were synthesized and evaluated for their SGLT inhibitory activity in brush border membrane vehicles (BBMVs) of rat kidney. O-glucosides of certain pyrazole analogues inhibited the transport of [(14)C]-glucose in BBMVs, and induced glucosuria in Wistar rats by intravenous injection.
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| http://dx.doi.org/10.1016/s0960-894x(03)00466-9 | DOI Listing |
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Pyrazole-O-glucosides as novel Na(+)-glucose cotransporter (SGLT) inhibitors.
Bioorg Med Chem Lett
July 2003
Pharmaceutical Research Laboratories, Pharmaceutical Company, Ajinomoto Co., Inc., 1-1, Suzuki-cho, Kawasaki-ku, 210-8681, Kawasaki, Japan.
O-glucuronides and O-glucosides of a series of pyrazoles analogues were synthesized and evaluated for their SGLT inhibitory activity in brush border membrane vehicles (BBMVs) of rat kidney. O-glucosides of certain pyrazole analogues inhibited the transport of [(14)C]-glucose in BBMVs, and induced glucosuria in Wistar rats by intravenous injection.
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