AI Article Synopsis
- - The study examined how dinner with alcoholic drinks impacts serum nitric oxide metabolites (NOx) in 11 healthy middle-aged men over a 3-week period.
- - Participants dined with four different beverages: red wine, beer, Dutch gin, or sparkling water, and serum NOx levels were measured at various times post-dinner.
- - Results showed a significant short-term increase in serum NOx levels after dinner, but this effect was reduced when alcohol was consumed; over time, moderate alcohol intake did not affect overall NOx levels.
Article Abstract
1. The present study investigated the acute and chronic effect of dinner with alcoholic beverages on serum nitric oxide (NO) metabolites, namely nitrate and nitrite (NOx), in 11 healthy, non-smoking middle-aged men. 2. In a randomized, diet-controlled, cross-over trial, subjects consumed dinner with four glasses of red wine, beer, spirits (Dutch gin) or sparkling mineral water (control) for 3 weeks. At the end of each 3 week period, serum NOx concentrations were measured just before and 1, 5 and 13 h after dinner. 3. Serum NOx concentrations were approximately 50% higher 1 and 5 h after dinner with any beverage compared with just before dinner (P = 0.0001). At 1 h after dinner, the serum NOx concentration was approximately 11% lower after dinner with alcoholic beverages compared with concentrations observed after dinner with water (P = 0.01). The fasted serum NOx concentration (13 h after dinner) was similar to the preprandial concentration and there were no differences in serum NOx concentrations between the alcoholic beverages. 4. Food intake acutely and transiently increased serum NOx concentrations, an effect that was slightly attenuated if combined with alcoholic beverages. Chronic moderate alcohol consumption had no effect on serum NOx concentration.
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| http://dx.doi.org/10.1046/j.1440-1681.2003.03863.x | DOI Listing |
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