Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4088/jcp.v64n0618a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genetic Variants and Major Depressive Disorder: A Systematic Review.
Pharmaceuticals (Basel)
October 2024
Clinical Analysis Laboratory, Molecular Pathology Sector, Pharmacy Department, Faculty of Ceilândia, University of Brasília (UnB), Brasília-Federal District (DF), Brasília 72220-900, Brazil.
Article Synopsis
- Major depressive disorder (MDD) impacts over 300 million people worldwide and has various causes, with the CYP2C19 enzyme affecting how some antidepressants are metabolized.
- A systematic review followed specific protocols and found only nine relevant studies from 240 articles that met inclusion criteria regarding gene variant frequencies and their effects on MDD.
- While some genetic variants showed associations with MDD symptoms and treatment responses, results were inconsistent, indicating a need for more research to better understand these genetic influences on depression and improve treatment options.
Polygenic score analyses on antidepressant response in late-life depression, results from the IRL-GRey study.
Pharmacogenomics J
November 2024
Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, ON, Canada.
Late-life depression (LLD) is often accompanied by medical comorbidities such as psychiatric disorders and cardiovascular diseases, posing challenges to antidepressant treatment. Recent studies highlighted significant associations between treatment-resistant depression (TRD) and polygenic risk score (PRS) for attention deficit hyperactivity disorder (ADHD) in adults as well as a negative association between antidepressant symptom improvement with both schizophrenia and bipolar. Here, we sought to validate these findings with symptom remission in LLD.
View Article and Find Full Text PDFRole of histone deacetylases and their inhibitors in neurological diseases.
Pharmacol Res
October 2024
Department of Pediatrics, PICU, Shengjing Hospital of China Medical University, Shenyang 110004, China. Electronic address:
Article Synopsis
- * Studies have shown that HDACs are critical for understanding both normal and disease-related processes in the nervous system, highlighting their potential as targets for neurological disease research.
- * The review discusses how HDAC inhibitors could be effective in treating various nervous system diseases, while also addressing the current challenges and future possibilities in the development of these inhibitors.
Molecular genetic analysis of candidate genes for glutaric aciduria type II in a cohort of patients from Queensland, Australia.
Mol Genet Metab
August 2024
Mater Research Institute-University of Queensland, Translational Research Institute, 37 Kent St, Woolloongabba, QLD 4102, Australia. Electronic address:
Glutaric aciduria type II (GAII) is a heterogeneous genetic disorder affecting mitochondrial fatty acid, amino acid and choline oxidation. Clinical manifestations vary across the lifespan and onset may occur at any time from the early neonatal period to advanced adulthood. Historically, some patients, in particular those with late onset disease, have experienced significant benefit from riboflavin supplementation.
View Article and Find Full Text PDFHabenular volume changes after venlafaxine treatment in patients with major depression.
Psychiatry Clin Neurosci
August 2024
Service Hospitalo-Universitaire de Psychiatrie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Saclay, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.
Background: Habenula, a hub brain region controlling monoaminergic brain center, has been implicated in major depressive disorder (MDD) and as a possible target of antidepressant response. Nevertheless, the effect of antidepressant drug treatment on habenular volumes remains unknown. The objective of the present research was to study habenular volume change after antidepressant treatment in patients with MDD, and assess whether it is associated with clinical improvement.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!