The ups and downs of novel antiemetic drugs, part 2: an illustration.

J Clin Psychiatry

Neuroscience Education Institute in Carlsbad, Calif., and the Department of Psychiatry at the University of California San Diego, CA92009, USA.

Published: June 2003

AI Article Synopsis

  • Novel antiemetic drugs target neurokinin-1 or serotonin-3 receptors to prevent vomiting.
  • Studies on how substance P and serotonin work together in the brain are revealing new potential uses for neurokinin-1 antagonists.
  • These insights could lead to additional treatments for conditions like depression and stress beyond just anti-nausea effects.

Article Abstract

Novel antiemetic drugs block either neurokinin-1 receptors or serotonin-3 receptors. Research into the neuropharmacology of vomiting is providing insight into the ways substance P and serotonin interact within the central nervous system that could lead to additional applications of neurokinin-1 antagonists for the treatment of depression and stress.

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Source
http://dx.doi.org/10.4088/jcp.v64n0601DOI Listing

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