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We present a case of a rare vascular variation of the persistent hypoglossal artery (PHA) in a 57-year-old Caucasian female patient with a medical history of poorly controlled hypertension, headaches, diabetes mellitus, and depression. This anatomical variation was initially misdiagnosed as an internal carotid artery (ICA) aneurysm during the extracranial carotid Doppler imaging conducted due to nonspecific symptoms of cerebrovascular insufficiency, manifesting as coordination disturbances. PHA is one of the four vertebrobasilar anastomoses, originating from the cervical segment of the ICA.

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Background: Extracranial hypoglossal schwannomas are rare, and transcranial skull base surgery can be challenging due to their proximity to the lower cranial nerves, jugular vein, vertebral artery, and carotid artery. The application of neuroendoscopic surgery for extracranial hypoglossal schwannomas has rarely been reported.

Case Description: A 53-year-old woman previously underwent lateral suboccipital surgery for a hypoglossal schwannoma when she was 25 years old.

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Rare neurovascular variants that you probably have not seen before.

Interv Neuroradiol

August 2024

Departments of Neurology, Neurosurgery, and Radiology, Boston Medical Center, Boston, MA, USA.

Article Synopsis
  • Understanding neurovascular variants is essential for ensuring safe procedures in endovascular and neurosurgery, as these variations can impact treatment outcomes.
  • The study reviewed uncommon neurovascular variants by analyzing a maintained neurovascular database and provided pictorial evidence along with insights on their embryology, clinical significance, and potential complications.
  • The findings include a variety of anatomical anomalies both in the brain and outside of it, which can influence diagnosis and interventions; thus, raising awareness among healthcare professionals is critical for patient safety.
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The jugular foramen, also known as the foramen magnum, is a highly intricate region of the skull base through which numerous critical blood vessels and nerves traverse. Meningiomas, the most common tumors in neurosurgical pathology, can arise at any location where the meninges are present, posing significant challenges. Meningiomas involving the jugular foramen and sublingual neural tube are particularly notable for their potential to extend from intracranial to extracranial sites, necessitating familiarity with extracranial anatomy, which is not typically encountered in clinical practice.

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Schwannomas are benign, slow-growing tumors originating from the Schwann cells of nerve sheaths. Extracranial schwannomas are rare, particularly in pediatric populations. Here, we report the case of a hypoglossal schwannoma in a 15-year-old male who experienced tongue paresthesia and fasciculations and difficulty swallowing two years before hospital admission.

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